Evidence supporting the use of: Acetyl-L-Carnitine-L-Arginine
For the body system: Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Acetyl-L-Carnitine and L-Arginine are two amino acid derivatives that have been studied for their potential roles in supporting the reproductive system, particularly in male fertility. Acetyl-L-Carnitine acts as an antioxidant and is involved in mitochondrial energy production, which is essential for sperm motility and function. Several clinical studies have demonstrated that supplementation with acetyl-L-carnitine, often in combination with L-carnitine, can improve sperm motility and overall semen quality in men with idiopathic infertility.[1]

L-Arginine is a precursor to nitric oxide, a molecule crucial for vasodilation and blood flow, which can influence erectile function. Some studies have shown that L-arginine supplementation can have a positive effect on erectile dysfunction and may also enhance sperm count and motility, though results are variable and effect sizes are moderate.[2]

While there is a reasonable body of scientific evidence supporting the use of these compounds—particularly in combination—for male reproductive health, the evidence is less robust for female reproductive support. Most clinical research has focused on male fertility parameters. The overall quality and quantity of evidence justify a moderate evidence rating.

[1] Lenzi, A. et al. (2004). Use of L-carnitine and acetyl-L-carnitine in male infertility. Reproductive BioMedicine Online, 9(6), 756-766.
[2] Stanislavov, R. et al. (2003). Treatment of erectile dysfunction with pycnogenol and L-arginine. Journal of Sex & Marital Therapy, 29(3), 207-213.

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