Evidence supporting the use of: Agnusides
For the body system: Reproductive System
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Agnusides are iridoid glycosides found primarily in the fruit of Vitex agnus-castus (chaste tree), a botanical traditionally used for various female reproductive health concerns. Modern research has investigated agnusides and related compounds for their potential effects on the reproductive system, particularly in the regulation of menstrual cycles and the management of premenstrual syndrome (PMS). Several clinical studies and reviews suggest that extracts of Vitex agnus-castus, standardized to agnusides, may alleviate symptoms of PMS, mastalgia (breast pain), and some menstrual irregularities. The presumed mechanism is modulation of pituitary hormones, notably a dopaminergic effect that indirectly reduces prolactin levels, potentially improving luteal phase defects. However, most studies use whole plant extracts rather than isolated agnusides, so evidence specific to agnusides is limited but consistent with the activity observed in the standardized extracts. Systematic reviews and meta-analyses (e.g., Cochrane reviews) generally conclude there is moderate evidence for chaste tree extract’s efficacy in PMS, though methodological quality varies. Overall, while further research is needed, the use of agnusides as part of Vitex agnus-castus extract for supporting aspects of the reproductive system is supported by a moderate level of scientific evidence.
Other ingredients that support Reproductive System
acetyl l-carnitineamino acids
ashwagandha
beta-sitosterol
black cohosh
bovine
bovine liver
broccoli
calcium
chaste tree
Chinese salvia root
choline
coenzyme Q10 (CoQ10)
turmeric
damiana
DHA (docosahexaeonic acid)
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dong quai root
EPA (eicosapentaenoic acid)
evening primrose oil
fennel
fenugreek
fish protein
flaxseed
folate
gamma linolenic acid (GLA)
ginger
ginseng
gokhru
hops
inositol
iodine
iron
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-arginine
l-carnitine
lactobacillus crispatus
lactobacillus jensenii
licorice root
lignans
linoleic acid (LA)
maca
magnesium
marine lipid
melatonin
moringa
motherwort
muira puama
omega-3 fatty acids
omega-6 fatty acids
pomegranate
protein
pumpkin
quail egg
raspberry
rehmannia glutinosa
saffron
saw palmetto
selenium
selenium
soybean
spearmint leaf
tongkat ali
tribulus
vitamin A
vitamin B
vitamin D
vitamin E
vitamin E
seaweed
water
wild yam
zinc
sarsaparilla
red clover
suma
squawvine
mugwort
nut grass
anise
punarnava
smilax
chaff flower
lingusticum wallichii
yarrow
cistanche
dioscorea
dodder
eucommia
ganoderma
lotus seed
morinda
royal jelly
Equol (proprietary)
guelder rose
trace minerals
anemarrhena asphodeloides
purslane
barrenwort
shepherd's purse
wood betony
hypothalamus
herbal blend (proprietary)
yohimbe
11-Ketotestosterone
25-d-spirosta-3, 5-diene
5-methyltetrahydrofolate glucosamine
8-Prenylnaringenin
Antler
Arachidonic Acid
Achyranthes
Anamu
Alchemilla
Aletris
Anserina
Aerva lanata
Agrimonia pilosa
Agnuside
Ashoka
Ant
Abuta
Allium tuberosum
Animal protein
Blue Cohosh
Babchi
Baliospermum
Black galingale
Beef
Beef liver
Bugbane
Bulbine natalensis
Black Gram
Banyan
Ba Ji Tian
Barbasco
Bee products
Borassus aethiopum
banana
Boerhavia diffusa
Calochortus
Curculigo orchicides
Cohosh
Clary sage
Chinese Mountain Ant
Cucurbita
Cod Liver Oil
Codonopsis
Cnidium
Clerodendrum phlomidis
Cynomorium
Cyathula
Chinese Pond Turtle
Chlorophytum
Chuchuhuasi
Casticin
Campylandra fimbriata
Catuaba
Costus
Carthamus
Canscora
DHEA
Daidzein
Deer Velvet
Dong Quai
Dibenzo-alpha pyrones
D-Pinitol
Diosgenin
Date
Egg
Euryale seed
Elk antler
Eicosapentaenoic Acid
Embelia
Estrogen
Folic Acid
False Unicorn Root
Isoflavones
Lotus
Orchid
yohimbine
Other body systems supported by Agnusides
DopamineEstrogen
Female Reproductive System
Glandular System
Hypothalamus
Ovaries
Pituitary
Pituitary (anterior)
Progesterone
Reproductive System
Specific Hormones
Uterus