Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, which is found in cruciferous vegetables like broccoli and Brussels sprouts. Its use in supporting the reproductive system—particularly for estrogen metabolism—has some basis in scientific research, though the evidence is still emerging and not definitive.

Several laboratory and animal studies suggest that DIM helps modulate estrogen metabolism by promoting the formation of beneficial estrogen metabolites, such as 2-hydroxyestrone, over potentially harmful ones like 16α-hydroxyestrone. This shift is theorized to support hormonal balance, which is relevant for both male and female reproductive health. In women, this has led to interest in DIM for conditions linked to estrogen dominance, such as premenstrual syndrome (PMS) and some symptoms of menopause. In men, DIM is sometimes explored for its possible effects on estrogen/testosterone balance.

Human clinical trials are limited and often small in size or preliminary in nature. Some pilot studies have examined DIM’s impact on conditions such as cervical dysplasia and prostate health, with mixed results. Current evidence does not strongly support its use for general reproductive system support in healthy individuals, but there is a plausible biological mechanism and some early-stage research suggesting a potential benefit. More robust, large-scale clinical trials are needed to establish efficacy and safety for reproductive health uses.