Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the body system: Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eicosapentaenoic acid (EPA), an omega-3 fatty acid found in fish oil, has some scientific evidence supporting its role in reproductive health, though the evidence is not robust and is primarily indirect. EPA is most studied for its anti-inflammatory effects and cardiovascular benefits, but its potential influence on the reproductive system is linked to modulation of inflammation, hormone synthesis, and possibly fertility outcomes. Some studies suggest that omega-3 fatty acids, including EPA, may improve endometrial receptivity and menstrual regularity, particularly in women with polycystic ovary syndrome (PCOS). For example, small clinical trials have reported improvements in ovulatory function and reductions in inflammation markers in women with reproductive disorders who supplement with omega-3s. In males, there is preliminary evidence that EPA may improve sperm quality parameters, such as motility and morphology, potentially via its anti-inflammatory and membrane-modifying effects. However, most clinical studies use mixtures of EPA and DHA, making it difficult to isolate EPA's specific effects. Large, well-controlled trials are lacking, and current reproductive health guidelines do not specifically endorse EPA supplementation for fertility or reproductive support. Thus, while there is some scientific rationale and early data suggesting a benefit, the overall evidence is limited and does not provide strong clinical validation.

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Other ingredients that support Reproductive System

25-d-spirosta-3, 5-diene
5-methyltetrahydrofolate glucosamine
8-Prenylnaringenin
Abuta
Acetyl L-carnitine
Achyranthes
Aerva lanata
Agnuside
Agrimonia pilosa
Alchemilla
Aletris
Allium tuberosum
amino acids
anamu
anemarrhena asphodeloides
animal protein
anise
Anserina
antler
arachidonic acid
Ashoka
ashwagandha
ba ji tian
babchi
Baliospermum
banana
banyan
barbasco
barrenwort
bee products
beef
Beef liver
beta-sitosterol
black cohosh
black galingale
black gram
blue cohosh
Boerhavia diffusa
Borassus aethiopum
bovine
bovine liver
broccoli
bugbane
Bulbine natalensis
calcium
Calochortus
Campylandra fimbriata
Canscora
Carthamus
casticin
catuaba
chaff flower
chaste tree
Chinese mountain ant
Chinese pond turtle
Chinese salvia root
Chlorophytum
choline
chuchuhuasi
cistanche
Clary sage
Clerodendrum phlomidis
Cnidium
cod liver oil
Codonopsis
coenzyme Q10 (CoQ10)
cohosh
costus
Cucurbita
Curculigo orchioides
Cyathula
Cynomorium
D-Pinitol
daidzein
damiana
date
deer velvet
DHA (docosahexaenoic acid)
DHEA
DHEA (dehydroepiandrosterone)
dibenzo-alpha pyrones
DIM (diindolylmethane)
dioscorea
diosgenin
dodder
dong quai
dong quai root
egg
eicosapentaenoic acid
elk antler
Embelia
EPA (eicosapentaenoic acid)
equol (proprietary)
estrogen
eucommia
Euryale seed
Eurycoma Longifolia
eurycomanone
evening primrose oil
Fadogia agrestis
false unicorn root
fatty acids
fennel
fenugreek
fish
fish protein
flaxseed
Flueggea suffruticosa
fo-ti
folate
folic acid
formononetin
furostanols
gamma linolenic acid (GLA)
ganoderma
giant trillium
ginger
ginseng
Ginsenosides
gokhru
Guava
guelder rose
Herb Robert
herbal blend (proprietary)
hops
horny goat weed
icariin
Indian fagonia
Indian sarsparilla
inositol
inositol phosphate
iodine
iron
isoflavones
Jatropha macrantha
jungli-bean
Kachnar
Kokilaksha
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-arginine
l-carnitine
Labisia pumila
Lactobacillus crispatus
Lactobacillus jensenii
Laminaria
Leptadenia
licorice root
lignans
ligustilides
Lilium polyphyllum
linoleic acid (LA)
lipids
lodhtree
long pepper
lotus
lotus seed
Lycium
maca
macaenes
macamides
magnesium
mandrake
maral root
Marine fat
Marine lipid
Matapalo Tree
Matico
Melatonin
Mezoneuron benthamianum
Millettia
Miroestrol
Montanoa tomentosa
Morinda
Moringa
Motherwort
Mugwort
Muira puama
Nigella seed
nut grass
Ocotillo
omega-3 fatty acids
omega-6 fatty acids
orchid
Orchis latifolia
Osthole
Paris polyphylla
Pedalium
Peptides
Petiveria
Phlomis umbrosa
Phyllanthus
Phytoestrogens
Piper chaba
Polygonum
polyunsaturated fat
pomegranate
Portulaca
probiotics
Propionyl-L-Carnitine
protein
Protodioscin
Puerain
Puerarin
pumpkin
punarnava
purslane
quail egg
raspberry
red clover
Rehmannia
rehmannia glutinosa
Rhaponticum
Rosa laevigata
royal jelly
Rubus
rue
Safed musli
saffron
Salvia
Sanguisorba
Sapogenin
sarsaparilla
saw palmetto
seaweed
selenium
selenium
Selenomethionine
Sensitive Plant
Shataverins
shepherd's purse
Shilajit
Sichuan Lovage
smilax
Soy
soybean
Sparganium
spearmint leaf
squawvine
suma
Szechuan lovage
Tongkat ali
trace minerals
Tree of heaven
tribulus
Tribulus Terrestris
Trichilia catigua
turmeric
Tynanthus panurensis
Vegetable Protein
Viburnum
Vidanga
vitamin A
vitamin B
vitamin D
vitamin E
vitamin E
Vitex Agnus-Castus
Vitexicarpin
Wild yam
Withanolides
Wood betony
Yarrow
Yohimbe
Yohimbine
Zedoary
Zinc

Products containing EPA (eicosapentaenoic acid)

Thorne Advanced DHA
Vitabase Complete Essential Fatty Acids
Pure Encapsulations DHA Ultimate
Pure Encapsulations DHA Ultimate
Pure Encapsulations EFA Essentials
Pure Encapsulations Energize Plus™ Pure Pack
Pure Encapsulations EPA/DHA
Pure Encapsulations EPA/DHA essentials 1,000 mg
Pure Encapsulations EPA/DHA essentials 1,000 mg
Vitabase EPA / DHA Omega-3
Pure Encapsulations EPA/DHA with Lemon
Pure Encapsulations EPA Ultimate
Klean Athlete Klean Omega ™
Douglas Laboratories Krill Oil
Pure Encapsulations Krill-Plex
Pure Encapsulations Krill-Plex
Metagenics MetaKids DHA
Pure Encapsulations NeuroMood Pure Pack
Pure Encapsulations O.N.E.™ Omega
Pure Encapsulations O.N.E.™ Omega
Thorne Omega-3 w/ CoQ10
Thorne Omega Superb Lemon Berry
Metagenics OmegaGenics Algae EPA-DHA 300 mg
Metagenics OmegaGenics EPA DHA 2400 Fish Oil
Metagenics OmegaGenics EPA-DHA 300 Lemon Lime
Metagenics OmegaGenics Fish Oil
Metagenics OmegaGenics Fish Oil EPA 1200 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 1000 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 1000 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 500 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 500 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil Mega 10®
Metagenics OmegaGenics Neuro 1000 mg
Designs For Health OmegAvail™ Hi-Po
Designs For Health OmegAvail™ Hi-Po
Designs For Health OmegAvail™ Hi-Po Liquid
Designs For Health OmegAvail™ Liquid
Designs For Health OmegAvail™ Synergy
Designs For Health OmegAvail™ Synergy
Designs For Health OmegAvail™ TG1000
Designs For Health OmegAvail™ Ultra
Designs For Health OmegAvail™ Ultra
Designs For Health OmegAvail™ Ultra DHA
Designs For Health OmegAvail™ Ultra with Vitamin D3, K1 and K2
Douglas Laboratories Opti-EPA 500 ™ Cholesterol Free
Douglas Laboratories Opti-EPA 500 ™ Cholesterol Free
Metagenics PlusOne® Daily Prenatal Packs
Thorne Prenatal DHA
Pure Encapsulations Pro-Resolve Omega
Thorne Pro-Resolving Mediators
Integrative Therapeutics Pure Omega HP
Integrative Therapeutics Pure Omega Liquid
Integrative Therapeutics Pure Omega Ultra HP
Pure Encapsulations PureNutrients EPA/DHA
Douglas Laboratories QÜELL® FISH OIL DHA Ultra SPM
Douglas Laboratories QUELL Fish Oil ® - EPA/DHA Plus D
Metagenics SPM Active
Thorne Super EPA
Thorne Super EPA NSF
Thorne Super EPA Pro
Vitabase Super Omega-3
Pure Encapsulations Ultra Pure Pack
Pure Encapsulations VisionPro EPA/DHA/GLA
Pure Encapsulations VisionPro EPA/DHA/GLA
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Designs For Health XanthOmega™ Krill Oil