Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the body system: Reproductive System

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eicosapentaenoic acid (EPA), an omega-3 fatty acid found in fish oil, has some scientific evidence supporting its role in reproductive health, though the evidence is not robust and is primarily indirect. EPA is most studied for its anti-inflammatory effects and cardiovascular benefits, but its potential influence on the reproductive system is linked to modulation of inflammation, hormone synthesis, and possibly fertility outcomes. Some studies suggest that omega-3 fatty acids, including EPA, may improve endometrial receptivity and menstrual regularity, particularly in women with polycystic ovary syndrome (PCOS). For example, small clinical trials have reported improvements in ovulatory function and reductions in inflammation markers in women with reproductive disorders who supplement with omega-3s. In males, there is preliminary evidence that EPA may improve sperm quality parameters, such as motility and morphology, potentially via its anti-inflammatory and membrane-modifying effects. However, most clinical studies use mixtures of EPA and DHA, making it difficult to isolate EPA's specific effects. Large, well-controlled trials are lacking, and current reproductive health guidelines do not specifically endorse EPA supplementation for fertility or reproductive support. Thus, while there is some scientific rationale and early data suggesting a benefit, the overall evidence is limited and does not provide strong clinical validation.

More about EPA (eicosapentaenoic acid)
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Other ingredients that support Reproductive System

Acetyl L-carnitine
amino acids
ashwagandha
beta-sitosterol
black cohosh
bovine
bovine liver
broccoli
calcium
chaste tree
Chinese salvia root
choline
coenzyme Q10 (CoQ10)
turmeric
damiana
DHA (docosahexaenoic acid)
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dong quai root
EPA (eicosapentaenoic acid)
evening primrose oil
fennel
fenugreek
fish protein
flaxseed
folate
gamma linolenic acid (GLA)
ginger
ginseng
gokhru
hops
inositol
iodine
iron
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-arginine
l-carnitine
Lactobacillus crispatus
Lactobacillus jensenii
licorice root
lignans
linoleic acid (LA)
maca
magnesium
Marine lipid
Melatonin
Moringa
Motherwort
Muira puama
omega-3 fatty acids
omega-6 fatty acids
pomegranate
protein
pumpkin
quail egg
raspberry
rehmannia glutinosa
saffron
saw palmetto
selenium
selenium
soybean
spearmint leaf
Tongkat ali
tribulus
vitamin A
vitamin B
vitamin D
vitamin E
vitamin E
seaweed
Water
Wild yam
Zinc
sarsaparilla
red clover
suma
squawvine
Mugwort
nut grass
anise
punarnava
smilax
chaff flower
Szechuan lovage
Yarrow
cistanche
dioscorea
dodder
eucommia
ganoderma
lotus seed
Morinda
royal jelly
equol (proprietary)
guelder rose
trace minerals
anemarrhena asphodeloides
purslane
barrenwort
shepherd's purse
Wood betony
herbal blend (proprietary)
Yohimbe
25-d-spirosta-3, 5-diene
5-methyltetrahydrofolate glucosamine
8-Prenylnaringenin
antler
arachidonic acid
Achyranthes
anamu
Alchemilla
Aletris
Anserina
Aerva lanata
Agrimonia pilosa
Agnuside
Ashoka
Abuta
Allium tuberosum
animal protein
blue cohosh
babchi
Baliospermum
black galingale
beef
Beef liver
bugbane
Bulbine natalensis
black gram
banyan
ba ji tian
barbasco
bee products
Borassus aethiopum
banana
Boerhavia diffusa
Calochortus
Curculigo orchioides
cohosh
Clary sage
Chinese mountain ant
Cucurbita
cod liver oil
Codonopsis
Cnidium
Clerodendrum phlomidis
Cynomorium
Cyathula
Chinese pond turtle
Chlorophytum
chuchuhuasi
casticin
Campylandra fimbriata
catuaba
costus
Carthamus
Canscora
DHEA
daidzein
deer velvet
dong quai
dibenzo-alpha pyrones
D-Pinitol
diosgenin
date
eurycomanone
egg
Euryale seed
elk antler
Eurycoma Longifolia
eicosapentaenoic acid
Embelia
estrogen
folic acid
Flueggea suffruticosa
fo-ti
furostanols
formononetin
fish
fatty acids
false unicorn root
Fadogia agrestis
Ginsenosides
Guava
giant trillium
horny goat weed
Herb Robert
Indian sarsparilla
isoflavones
long pepper
icariin
Indian fagonia
inositol phosphate
jungli-bean
Jatropha macrantha
Kachnar
Kokilaksha
Lycium
Lilium polyphyllum
ligustilides
lodhtree
lotus
Leptadenia
Laminaria
lipids
Labisia pumila
macamides
maral root
Mezoneuron benthamianum
Montanoa tomentosa
Matico
Matapalo Tree
Miroestrol
Marine fat
mandrake
Millettia
macaenes
Nigella seed
Ocotillo
Orchis latifolia
orchid
Osthole
Puerain
Phyllanthus
Puerarin
Piper chaba
Propionyl-L-Carnitine
polyunsaturated fat
Protodioscin
probiotics
Phlomis umbrosa
Paris polyphylla
Pedalium
Portulaca
Phytoestrogens
Polygonum
Petiveria
Peptides
rue
Rubus
Rehmannia
Rhaponticum
Rosa laevigata
Sapogenin
Sichuan Lovage
Soy
Selenomethionine
Salvia
Sensitive Plant
Sanguisorba
Safed musli
Shataverins
Shilajit
Sparganium
Tree of heaven
Trichilia catigua
Tynanthus panurensis
Tribulus Terrestris
Vegetable Protein
Vitexicarpin
Viburnum
Vidanga
Vitex Agnus-Castus
Withanolides
Yohimbine
Zedoary

Products containing EPA (eicosapentaenoic acid)

Thorne Advanced DHA
Vitabase Complete Essential Fatty Acids
Pure Encapsulations DHA Ultimate
Pure Encapsulations DHA Ultimate
Pure Encapsulations EFA Essentials
Pure Encapsulations Energize Plus™ Pure Pack
Pure Encapsulations EPA/DHA
Pure Encapsulations EPA/DHA essentials 1,000 mg
Pure Encapsulations EPA/DHA essentials 1,000 mg
Vitabase EPA / DHA Omega-3
Pure Encapsulations EPA/DHA with Lemon
Pure Encapsulations EPA Ultimate
Klean Athlete Klean Omega ™
Douglas Laboratories Krill Oil
Pure Encapsulations Krill-Plex
Pure Encapsulations Krill-Plex
Metagenics MetaKids DHA
Pure Encapsulations NeuroMood Pure Pack
Pure Encapsulations O.N.E.™ Omega
Pure Encapsulations O.N.E.™ Omega
Thorne Omega-3 w/ CoQ10
Thorne Omega Superb Lemon Berry
Metagenics OmegaGenics Algae EPA-DHA 300 mg
Metagenics OmegaGenics EPA DHA 2400 Fish Oil
Metagenics OmegaGenics EPA-DHA 300 Lemon Lime
Metagenics OmegaGenics Fish Oil
Metagenics OmegaGenics Fish Oil EPA 1200 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 1000 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 1000 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 500 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 500 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil Mega 10®
Metagenics OmegaGenics Neuro 1000 mg
Designs For Health OmegAvail™ Hi-Po
Designs For Health OmegAvail™ Hi-Po
Designs For Health OmegAvail™ Hi-Po Liquid
Designs For Health OmegAvail™ Liquid
Designs For Health OmegAvail™ Synergy
Designs For Health OmegAvail™ Synergy
Designs For Health OmegAvail™ TG1000
Designs For Health OmegAvail™ Ultra
Designs For Health OmegAvail™ Ultra
Designs For Health OmegAvail™ Ultra DHA
Designs For Health OmegAvail™ Ultra with Vitamin D3, K1 and K2
Douglas Laboratories Opti-EPA 500 ™ Cholesterol Free
Douglas Laboratories Opti-EPA 500 ™ Cholesterol Free
Metagenics PlusOne® Daily Prenatal Packs
Thorne Prenatal DHA
Pure Encapsulations Pro-Resolve Omega
Thorne Pro-Resolving Mediators
Integrative Therapeutics Pure Omega HP
Integrative Therapeutics Pure Omega Liquid
Integrative Therapeutics Pure Omega Ultra HP
Pure Encapsulations PureNutrients EPA/DHA
Douglas Laboratories QÜELL® FISH OIL DHA Ultra SPM
Douglas Laboratories QUELL Fish Oil ® - EPA/DHA Plus D
Metagenics SPM Active
Thorne Super EPA
Thorne Super EPA NSF
Thorne Super EPA Pro
Vitabase Super Omega-3
Pure Encapsulations Ultra Pure Pack
Pure Encapsulations VisionPro EPA/DHA/GLA
Pure Encapsulations VisionPro EPA/DHA/GLA
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Designs For Health XanthOmega™ Krill Oil