Synopsis

Source of validity: Scientific
Rating (out of 5): 4

L-5-Methyltetrahydrofolate glucosamine salt (5-MTHF) is the biologically active form of folate, a B-vitamin essential for DNA synthesis, methylation, and cell division. Its role in supporting the reproductive system is well-documented and scientifically validated, particularly regarding fertility, pregnancy, and fetal development. Folate deficiency in women of reproductive age is associated with increased risk of neural tube defects (NTDs) in offspring, making adequate folate crucial before and during pregnancy. Traditional folic acid supplements require enzymatic conversion to 5-MTHF in the body; however, a significant proportion of the population has genetic polymorphisms (such as MTHFR mutations) that reduce this conversion efficiency. Supplementing directly with 5-MTHF bypasses this metabolic bottleneck, ensuring effective folate availability.

Multiple clinical studies and authoritative health organizations (e.g., CDC, WHO) recommend folate supplementation for women planning pregnancy. Emerging evidence suggests that 5-MTHF may be superior to folic acid for individuals with MTHFR variants, potentially further reducing the risk of NTDs and supporting overall reproductive health. Additionally, folate is involved in spermatogenesis, and its deficiency may impair male fertility. While most research focuses on NTD prevention, the underlying mechanisms—support of DNA methylation, cell division, and amino acid metabolism—are critical to multiple aspects of reproductive function. Therefore, the use of 5-MTHF is scientifically justified in supporting the reproductive system, with a robust evidence base, especially for preconception and prenatal health.

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Products containing l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)

Thorne Multi-Vitamin Elite NSF