Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E, including its water-soluble derivative alpha-tocopheryl polyethylene glycol succinate (TPGS), is supported by scientific evidence for its role in reproductive system health. Vitamin E is a potent antioxidant that protects cell membranes from oxidative damage, which is crucial for the normal function of reproductive organs. In males, vitamin E has been shown in several animal and human studies to improve sperm quality, motility, and overall fertility by reducing oxidative stress in semen. For females, vitamin E's antioxidant properties may protect oocytes and support endometrial health, potentially benefiting fertility outcomes. Historical data also indicate that vitamin E deficiency in animals leads to reproductive failure and spontaneous abortion, emphasizing its fundamental role.

Clinical studies in humans are more limited but suggest a positive effect of vitamin E supplementation on sperm parameters and, in some cases, pregnancy rates, particularly in couples with unexplained infertility or oxidative stress-related infertility. However, results are mixed, and some studies show little to no benefit, especially in the absence of a deficiency state. It is important to note that TPGS, the specific derivative mentioned, is primarily used to enhance the bioavailability of poorly soluble drugs and supplements, and not specifically for its reproductive effects. Nonetheless, the biological activity of vitamin E itself as an antioxidant underlies its supportive role in reproductive health.

In summary, while there is scientific validation, particularly from antioxidant-related mechanisms, the evidence is moderate, with clear benefits in deficiency states but less certainty for supplementation in otherwise healthy individuals.

More about Vitamin E (alpha-tocopheryl polyethylene glycol succinate)
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Other body systems supported by Vitamin E (alpha-tocopheryl polyethylene glycol succinate)

Circulatory System
Heart
Immune System
Male Reproductive System
Reproductive System
Skin

Products containing Vitamin E (alpha-tocopheryl polyethylene glycol succinate)

We currently have no products on Vitabase that contain this ingredient.