Relationship: Respiratory System and vitamin D3

Evidence supporting the use of: Vitamin D3
For the body system: Respiratory System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D3 (cholecalciferol) is primarily known for its role in bone health and calcium metabolism, but there is emerging scientific evidence supporting its involvement in the respiratory system. Vitamin D receptors are present in many immune cells, and vitamin D has immunomodulatory effects that influence both innate and adaptive immunity. Several observational studies have found that individuals with low vitamin D levels are at increased risk for acute respiratory infections, including influenza and pneumonia. Some randomized controlled trials (RCTs) suggest that vitamin D supplementation can reduce the risk of respiratory tract infections, particularly in individuals who are deficient. For example, a 2017 meta-analysis published in BMJ found that vitamin D supplementation was associated with a reduced risk of acute respiratory infections, especially in those with baseline deficiency.

However, the evidence is mixed, with some trials showing no significant benefit. During the COVID-19 pandemic, interest in vitamin D's role in respiratory health increased, and while some studies suggested potential protective effects, others did not confirm these findings. Guidelines from health organizations do not universally recommend vitamin D supplementation solely for respiratory health unless there is a deficiency. In summary, while there is moderate scientific support for vitamin D3’s role in supporting the respiratory system—mainly through immune modulation and infection risk reduction—the evidence is not unequivocal, and supplementation should be targeted to those with deficiency or at high risk.

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Other body systems supported by vitamin D3

Blood
Brain
Circulatory System
Glandular System
Heart
Immune System
Intestinal System
Kidneys
Lungs
Mitochondria
Muscles
Parathyroid Glands
Respiratory System
Skeletal System (Bones)
Skin
Small Intestines
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Evidence supporting the use of: Vitamin D3
For the body system: Respiratory System

Table of Contents

Synopsis

Other ingredients that support Respiratory System

Other body systems supported by vitamin D3

Products containing vitamin D3

Health Concerns

Brands

Evidence supporting the use of: Vitamin D3For the body system: Respiratory System

Table of Contents

Synopsis

Other ingredients that support Respiratory System

Other body systems supported by vitamin D3

Products containing vitamin D3

Evidence supporting the use of: Vitamin D3
For the body system: Respiratory System