Evidence supporting the use of: Acetylsalicylic acid
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Acetylsalicylic acid, commonly known as aspirin, has a well-established history in the treatment of rheumatoid arthritis (RA). Its use is scientifically validated, dating back to the late 19th and early 20th centuries when it was among the first nonsteroidal anti-inflammatory drugs (NSAIDs) utilized for inflammatory conditions. Aspirin exerts its effects by irreversibly inhibiting cyclooxygenase (COX) enzymes, which play a critical role in the synthesis of prostaglandins—mediators of inflammation and pain. Clinical studies throughout the 20th century demonstrated that aspirin effectively reduces joint pain, swelling, and stiffness in RA patients, allowing for improved mobility and quality of life. However, while aspirin was once a mainstay of RA therapy, its use has declined with the advent of newer NSAIDs and disease-modifying antirheumatic drugs (DMARDs), which provide similar or superior efficacy with improved gastrointestinal safety profiles. Nonetheless, the mechanism of action and benefits of acetylsalicylic acid in RA are well-understood and documented in medical literature. Today, aspirin may still be used in select cases, particularly where other NSAIDs are contraindicated or unavailable, but it is no longer considered first-line therapy due to its side effect profile, especially gastrointestinal toxicity at anti-inflammatory doses. In summary, the use of acetylsalicylic acid in rheumatoid arthritis is strongly supported by scientific evidence, although its clinical role has diminished with evolving therapeutic options.

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