Evidence supporting the use of: Alpha-Lipoic Acid
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-lipoic acid (ALA) is an endogenous antioxidant that has been studied for its potential anti-inflammatory properties, which has led to some scientific interest in its use for inflammatory conditions such as rheumatoid arthritis (RA). Several in vitro and animal studies have demonstrated that ALA can reduce markers of inflammation and oxidative stress, both of which are implicated in the pathogenesis of RA. Furthermore, ALA has been shown to inhibit the activation of nuclear factor-kappa B (NF-κB), a key regulator of inflammatory cytokine production relevant to RA.

A small number of human studies and clinical trials have evaluated the effects of ALA in patients with RA or related inflammatory arthritis. For example, a 2020 randomized controlled trial found that ALA supplementation, in combination with methotrexate, modestly improved oxidative stress markers and reduced some inflammatory parameters in RA patients. However, the number of trials is limited, sample sizes are small, and results are inconsistent regarding clinical outcomes such as pain and joint function.

In summary, while there is a scientific rationale for the use of ALA in RA based on its antioxidant and anti-inflammatory properties, and some preliminary human studies suggest possible benefits, the overall quality and quantity of evidence are insufficient to support its widespread use as an adjunct therapy for RA at this time.

More about Alpha-Lipoic Acid
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

adrenal cortex
Alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-pinene
anthocyanins
ashwagandha
astaxanthin
borage oil
celery
coenzyme Q10 (CoQ10)
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
dong quai root
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
evening primrose oil
fisetin
fish protein
gamma linolenic acid (GLA)
gamma tocopherol
genistein
ginger
green lipped mussel
krill oil
luteolin
methylsulfonylmethane (MSM)
myristoleate
omega-3 fatty acids
phospholipids
resveratrol
rose hips
sardines
slippery elm bark
sulforaphane glucosinolate
Urolithin A
vitamin B6
vitamin C
vitamin D
vitamin D3
watercress
white willow
alpinia galangal
smilax
fumaria parviflora
Szechuan lovage
amber
teasel
guelder rose
gentiana macrophylla
Abies spectabilis
AMP-activated protein kinase (AMPK)
clematis
15,16-Dihydrotanshinone I
Aralia
Akebia
Antler
Apigenin
Abrus
Andrographolide
Amentoflavone
Alpha-Lipoic Acid
anthocyanidins
Ampelopsin
Actaea spicata
Arjunic Acid
Apocynin
Arctiin
Astragalin
Boswellic Acid
Baicalein
Bogbean
Boswellia
Black willow
Barbasco
bovine cartilage / glycosaminoglycan
Baicalin
Black Hellebore
Bee venom
Bergenia
Cod Liver Oil
Cortisol
Clerodendrum phlomidis
Cyanidin
Chinese Fleeceflower
Chinese Pond Turtle
Chuchuhuasi
Cetylated Fatty Acids
C-Phycocyanin
Cannabidiol
Carnosic acid
Docosahexaenoic Acid
Dihomo-gamma-linolenic acid
Eicosatetraenoic acid
Eicosapentaenoic Acid
Evening Primrose Oil
Fat liver oil
Fructoborate
Flemingia philippinensis
Frankincense
Flavanols
Flavones
Ginkgetin
Gypenoside
Horse Gram
Hyperoside
Hellebore
Hydroxytyrosol
Harpagoside
Jatropha macrantha
Kaempferol
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Myricetin
Madder
Marine fat
Nobiletin
Osthole
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Piper chaba
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Palmitoylethanolamide (PEA)
Qin Jiao
Silkmoth
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Schizochytrium
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Salvianolic acid
Sinomenium acutum
Semecarpus anacardium
saponins
Shilajit
Stearidonic acid
Sulforaphane
Taxillus chinensis
Tanshinone
Uncaria
Ursolic Acid
Withanolides

Products containing Alpha-Lipoic Acid

We currently have no products on Vitabase that contain this ingredient.