Evidence supporting the use of: Ampelopsin
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ampelopsin, also known as dihydromyricetin, is a flavonoid compound primarily found in Ampelopsis grossedentata. There is some scientific interest in its potential anti-inflammatory and immunomodulatory effects. Preclinical studies, especially those conducted in vitro and in animal models, have suggested that ampelopsin can inhibit the production of pro-inflammatory cytokines, such as TNF-α and IL-1β, and suppress the activation of key signaling pathways implicated in the pathogenesis of rheumatoid arthritis (RA), including NF-κB and MAPK pathways. For example, a 2018 study in the journal International Immunopharmacology reported that ampelopsin attenuated inflammatory responses in collagen-induced arthritis models in mice, reducing joint swelling and histopathological signs of inflammation.

However, while these findings are promising, there is a lack of robust human clinical trials evaluating the efficacy and safety of ampelopsin in RA patients. Most evidence to date is limited to laboratory and animal research, and no major rheumatology guidelines currently recognize ampelopsin as a treatment for RA. Thus, while the use of ampelopsin for rheumatoid arthritis is supported by preliminary scientific studies, the overall quality and quantity of evidence remain low, reflecting a need for further well-designed clinical studies to confirm these effects in humans.

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