Evidence supporting the use of: Ampelopsin
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ampelopsin, also known as dihydromyricetin, is a flavonoid compound primarily found in Ampelopsis grossedentata. There is some scientific interest in its potential anti-inflammatory and immunomodulatory effects. Preclinical studies, especially those conducted in vitro and in animal models, have suggested that ampelopsin can inhibit the production of pro-inflammatory cytokines, such as TNF-α and IL-1β, and suppress the activation of key signaling pathways implicated in the pathogenesis of rheumatoid arthritis (RA), including NF-κB and MAPK pathways. For example, a 2018 study in the journal International Immunopharmacology reported that ampelopsin attenuated inflammatory responses in collagen-induced arthritis models in mice, reducing joint swelling and histopathological signs of inflammation.

However, while these findings are promising, there is a lack of robust human clinical trials evaluating the efficacy and safety of ampelopsin in RA patients. Most evidence to date is limited to laboratory and animal research, and no major rheumatology guidelines currently recognize ampelopsin as a treatment for RA. Thus, while the use of ampelopsin for rheumatoid arthritis is supported by preliminary scientific studies, the overall quality and quantity of evidence remain low, reflecting a need for further well-designed clinical studies to confirm these effects in humans.

More about ampelopsin
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Other ingredients used for Rheumatoid Arthritis

15,16-Dihydrotanshinone I
Abies spectabilis
Abrus
Actaea spicata
adrenal cortex
Akebia
Alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-lipoic acid
alpha-pinene
alpinia galangal
amber
amentoflavone
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
anthocyanidins
anthocyanins
antler
apigenin
apocynin
Aralia
arctiin
arjunic acid
ashwagandha
astaxanthin
astragalin
baicalein
baicalin
barbasco
bee venom
Bergenia
Black Hellebore
Black willow
bogbean
borage oil
Boswellia
Boswellic Acid
bovine cartilage / glycosaminoglycan
C-phycocyanin
cannabidiol
carnosic acid
celery
Cetylated Fatty Acids
Chinese fleeceflower
Chinese pond turtle
chuchuhuasi
clematis
Clerodendrum phlomidis
cod liver oil
coenzyme Q10 (CoQ10)
cortisol
curcumin
cyanidin
d-alpha tocopherol
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
Dihomo-gamma-linolenic acid
docosahexaenoic Acid
dong quai root
DPA (docosapentaenoic acid)
eicosapentaenoic acid
Eicosatetraenoic acid
EPA (eicosapentaenoic acid)
evening primrose oil
evening primrose oil
fat liver oil
fisetin
fish protein
flavanols
flavones
Flemingia philippinensis
frankincense
fructoborate
Fumaria parviflora
gamma linolenic acid (GLA)
gamma tocopherol
genistein
Gentiana macrophylla
ginger
ginkgetin
green-lipped mussel
guelder rose
Gypenoside
Harpagoside
Hellebore
horse gram
hydroxytyrosol
Hyperoside
Jatropha macrantha
Kaempferol
krill oil
luteolin
madder
mangiferin
Marine fat
Methylsulfonylmethane (MSM)
Myricetin
Myristoleate
Nobiletin
omega-3 fatty acids
Osthole
Palmitoylethanolamide (PEA)
Phaeophyceae
phospholipids
Piper chaba
Polydatin
polyunsaturated fat
proteoglycans
Puerarin
Qin Jiao
resveratrol
rose hips
Salicin
Salmon Oil
Salvianolic acid
saponins
Schizochytrium
Schizochytrium Oil
Semecarpus anacardium
Shilajit
Silkmoth
Sinomenium acutum
slippery elm bark
smilax
Stearidonic acid
Sulforaphane
sulforaphane glucosinolate
Szechuan lovage
Tanshinone
Taxillus chinensis
teasel
turmeric
Uncaria
Urolithin A
Ursolic Acid
vitamin B6
vitamin C
vitamin D
vitamin D3
Watercress
white willow
Withanolides

Products containing ampelopsin

We currently have no products on Vitabase that contain this ingredient.