Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Anthocyanins are a group of flavonoid pigments found in various fruits and vegetables, most notably in berries, red grapes, and purple sweet potatoes. Their use in supporting or treating Rheumatoid Arthritis (RA) is primarily grounded in scientific investigation rather than longstanding traditional use. Preclinical studies and some small-scale clinical trials suggest that anthocyanins possess significant antioxidant and anti-inflammatory properties. These properties are relevant to RA, a chronic autoimmune disease characterized by inflammation and oxidative stress in the joints.

Research has shown that anthocyanins can inhibit the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, and suppress the activity of enzymes like COX-2 and iNOS, which are involved in inflammation. Animal models of arthritis have demonstrated that anthocyanin-rich extracts can reduce joint swelling, cartilage destruction, and inflammatory markers. Some human studies, though limited in size and scope, indicate potential benefits of anthocyanin supplementation in reducing inflammatory markers and improving symptoms in individuals with RA and other inflammatory conditions.

However, the clinical evidence is still preliminary, with most studies characterized by small sample sizes, short durations, and variability in anthocyanin sources and dosages. Thus, while there is a scientific rationale and early evidence supporting the use of anthocyanins for RA, more robust, large-scale clinical trials are needed to confirm their efficacy and establish appropriate dosing strategies. As such, the evidence supporting their use is rated as moderate but not yet strong.

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Douglas Laboratories Ultra Preventive 50+ -EZ Swallow