Evidence supporting the use of: Apigenin
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Apigenin is a naturally occurring flavonoid found in various plants, including parsley, chamomile, and celery. Its use in supporting or potentially treating rheumatoid arthritis (RA) is primarily based on preclinical scientific research rather than traditional medicine. Several in vitro and animal studies have demonstrated that apigenin possesses anti-inflammatory, antioxidant, and immunomodulatory properties. Specifically, apigenin has been shown to inhibit key pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6) and to suppress the activation of the NF-κB pathway, which plays a central role in the inflammatory processes underlying RA. In murine models of arthritis, apigenin treatment reduced joint swelling, cartilage destruction, and inflammatory cell infiltration. Despite these promising findings, there is a lack of robust clinical evidence in humans. No significant randomized controlled trials have been published to confirm efficacy or safety of apigenin supplementation for RA patients. Therefore, while scientific research supports a theoretical basis and preliminary efficacy in animal models, the overall evidence remains limited and does not yet justify apigenin as a standalone or adjunctive treatment for RA in clinical practice.

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Products containing Apigenin

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