Evidence supporting the use of: Apocynin
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Apocynin is a natural compound derived from the root of Picrorhiza kurroa and has been studied for its anti-inflammatory and antioxidant properties, particularly its ability to inhibit NADPH oxidase-mediated production of reactive oxygen species (ROS). In the context of rheumatoid arthritis (RA), a chronic autoimmune disease characterized by joint inflammation and tissue destruction, ROS play a significant role in propagating inflammation and joint damage.

Preclinical studies, primarily in animal models of arthritis, have shown that apocynin administration can reduce inflammation, oxidative stress, and joint destruction. For example, several rodent studies have demonstrated that apocynin treatment leads to decreased joint swelling, lower levels of pro-inflammatory cytokines, and reduced histopathological evidence of arthritis. The proposed mechanism involves inhibition of NADPH oxidase, resulting in less ROS production and downstream inflammatory signaling.

However, robust clinical evidence in humans with RA is lacking. Most of the available data are limited to in vitro experiments and animal models, and there are no well-designed, large-scale human clinical trials confirming efficacy or safety for RA patients. Therefore, while there is a scientific rationale and encouraging preclinical data, the overall quality and quantity of evidence supporting apocynin's use in RA is limited. Its use is not established in clinical practice, and further research is needed before it can be recommended for routine RA management.

More about apocynin
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Other ingredients used for Rheumatoid Arthritis

15,16-Dihydrotanshinone I
Abies spectabilis
Abrus
Actaea spicata
adrenal cortex
Akebia
Alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-lipoic acid
alpha-pinene
alpinia galangal
amber
amentoflavone
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
anthocyanidins
anthocyanins
antler
apigenin
apocynin
Aralia
arctiin
arjunic acid
ashwagandha
astaxanthin
astragalin
baicalein
baicalin
barbasco
bee venom
Bergenia
Black Hellebore
Black willow
bogbean
borage oil
Boswellia
Boswellic Acid
bovine cartilage / glycosaminoglycan
C-phycocyanin
cannabidiol
carnosic acid
celery
Cetylated Fatty Acids
Chinese fleeceflower
Chinese pond turtle
chuchuhuasi
clematis
Clerodendrum phlomidis
cod liver oil
coenzyme Q10 (CoQ10)
cortisol
curcumin
cyanidin
d-alpha tocopherol
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
Dihomo-gamma-linolenic acid
docosahexaenoic Acid
dong quai root
DPA (docosapentaenoic acid)
eicosapentaenoic acid
Eicosatetraenoic acid
EPA (eicosapentaenoic acid)
evening primrose oil
evening primrose oil
fat liver oil
fisetin
fish protein
flavanols
flavones
Flemingia philippinensis
frankincense
fructoborate
Fumaria parviflora
gamma linolenic acid (GLA)
gamma tocopherol
genistein
Gentiana macrophylla
ginger
ginkgetin
green-lipped mussel
guelder rose
Gypenoside
Harpagoside
Hellebore
horse gram
hydroxytyrosol
Hyperoside
Jatropha macrantha
Kaempferol
krill oil
luteolin
madder
mangiferin
Marine fat
Methylsulfonylmethane (MSM)
Myricetin
Myristoleate
Nobiletin
omega-3 fatty acids
Osthole
Palmitoylethanolamide (PEA)
Phaeophyceae
phospholipids
Piper chaba
Polydatin
polyunsaturated fat
proteoglycans
Puerarin
Qin Jiao
resveratrol
rose hips
Salicin
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Salvianolic acid
saponins
Schizochytrium
Schizochytrium Oil
Semecarpus anacardium
Shilajit
Silkmoth
Sinomenium acutum
slippery elm bark
smilax
Stearidonic acid
Sulforaphane
sulforaphane glucosinolate
Szechuan lovage
Tanshinone
Taxillus chinensis
teasel
turmeric
Uncaria
Urolithin A
Ursolic Acid
vitamin B6
vitamin C
vitamin D
vitamin D3
Watercress
white willow
Withanolides

Products containing apocynin

We currently have no products on Vitabase that contain this ingredient.