Evidence supporting the use of: Arctiin
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Arctiin is a lignan compound found primarily in the seeds of Arctium lappa (burdock). Recent scientific studies have investigated its potential anti-inflammatory and immunomodulatory properties, which are relevant to autoimmune diseases such as rheumatoid arthritis (RA). Several in vitro and animal studies have shown that arctiin can inhibit the production of pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6) and suppress the activation of NF-κB, a key transcription factor in inflammation. Notably, a few studies using collagen-induced arthritis models in mice have reported that arctiin administration reduced joint swelling, cartilage destruction, and inflammatory cell infiltration. These effects are thought to be mediated by downregulation of inflammatory signaling pathways and oxidative stress. However, the evidence remains preclinical: there are no published randomized controlled trials or robust clinical studies in humans assessing the efficacy or safety of arctiin for rheumatoid arthritis. Moreover, while burdock root has traditional uses in herbal medicine for inflammatory conditions, the specific use of isolated arctiin for RA is not established in traditional medical systems. Therefore, while the compound shows promise in laboratory and animal models, the current evidence base to support its use in humans with RA is limited and insufficient for clinical recommendation.

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