Evidence supporting the use of: Arctiin
For the health condition: Rheumatoid Arthritis
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Arctiin is a lignan compound found primarily in the seeds of Arctium lappa (burdock). Recent scientific studies have investigated its potential anti-inflammatory and immunomodulatory properties, which are relevant to autoimmune diseases such as rheumatoid arthritis (RA). Several in vitro and animal studies have shown that arctiin can inhibit the production of pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6) and suppress the activation of NF-κB, a key transcription factor in inflammation. Notably, a few studies using collagen-induced arthritis models in mice have reported that arctiin administration reduced joint swelling, cartilage destruction, and inflammatory cell infiltration. These effects are thought to be mediated by downregulation of inflammatory signaling pathways and oxidative stress. However, the evidence remains preclinical: there are no published randomized controlled trials or robust clinical studies in humans assessing the efficacy or safety of arctiin for rheumatoid arthritis. Moreover, while burdock root has traditional uses in herbal medicine for inflammatory conditions, the specific use of isolated arctiin for RA is not established in traditional medical systems. Therefore, while the compound shows promise in laboratory and animal models, the current evidence base to support its use in humans with RA is limited and insufficient for clinical recommendation.
Other ingredients used for Rheumatoid Arthritis
adrenal cortexAlfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-pinene
anthocyanins
ashwagandha
astaxanthin
borage oil
celery
coenzyme Q10 (CoQ10)
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
dong quai root
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
evening primrose oil
fisetin
fish protein
gamma linolenic acid (GLA)
gamma tocopherol
genistein
ginger
green lipped mussel
krill oil
luteolin
methylsulfonylmethane (MSM)
myristoleate
omega-3 fatty acids
phospholipids
resveratrol
rose hips
sardines
slippery elm bark
sulforaphane glucosinolate
Urolithin A
vitamin B6
vitamin C
vitamin D
vitamin D3
watercress
white willow
alpinia galangal
smilax
fumaria parviflora
Szechuan lovage
amber
teasel
guelder rose
gentiana macrophylla
Abies spectabilis
AMP-activated protein kinase (AMPK)
clematis
15,16-Dihydrotanshinone I
Aralia
Akebia
Antler
Apigenin
Abrus
Andrographolide
Amentoflavone
Alpha-Lipoic Acid
anthocyanidins
Ampelopsin
Actaea spicata
Arjunic Acid
Apocynin
Arctiin
Astragalin
Boswellic Acid
Baicalein
Bogbean
Boswellia
Black willow
Barbasco
bovine cartilage / glycosaminoglycan
Baicalin
Black Hellebore
Bee venom
Bergenia
Cod Liver Oil
Cortisol
Clerodendrum phlomidis
Cyanidin
Chinese Fleeceflower
Chinese Pond Turtle
Chuchuhuasi
Cetylated Fatty Acids
C-Phycocyanin
Cannabidiol
Carnosic acid
Docosahexaenoic Acid
Dihomo-gamma-linolenic acid
Eicosatetraenoic acid
Eicosapentaenoic Acid
Evening Primrose Oil
Fat liver oil
Fructoborate
Flemingia philippinensis
Frankincense
Flavanols
Flavones
Ginkgetin
Gypenoside
Horse Gram
Hyperoside
Hellebore
Hydroxytyrosol
Harpagoside
Jatropha macrantha
Kaempferol
Mangiferin
Myricetin
Madder
Marine fat
Nobiletin
Osthole
Puerarin
Piper chaba
Phaeophyceae
Proteoglycans
Polydatin
Polyunsaturated Fat
Palmitoylethanolamide (PEA)
Qin Jiao
Silkmoth
Schizochytrium Oil
Schizochytrium
Salicin
Salmon Oil
Salvianolic acid
Sinomenium acutum
Semecarpus anacardium
saponins
Shilajit
Stearidonic acid
Sulforaphane
Taxillus chinensis
Tanshinone
Uncaria
Ursolic Acid
Withanolides
Other health conditions supported by Arctiin
Cancer (natural therapy for)Cancer (prevention)
Diabetes
Free Radical Damage
Inflammation
Inflammatory Bowel Disorders
Osteoporosis
Rheumatoid Arthritis