Evidence supporting the use of: Arctiin
For the health condition: Rheumatoid Arthritis
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Arctiin is a lignan compound found primarily in the seeds of Arctium lappa (burdock). Recent scientific studies have investigated its potential anti-inflammatory and immunomodulatory properties, which are relevant to autoimmune diseases such as rheumatoid arthritis (RA). Several in vitro and animal studies have shown that arctiin can inhibit the production of pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6) and suppress the activation of NF-κB, a key transcription factor in inflammation. Notably, a few studies using collagen-induced arthritis models in mice have reported that arctiin administration reduced joint swelling, cartilage destruction, and inflammatory cell infiltration. These effects are thought to be mediated by downregulation of inflammatory signaling pathways and oxidative stress. However, the evidence remains preclinical: there are no published randomized controlled trials or robust clinical studies in humans assessing the efficacy or safety of arctiin for rheumatoid arthritis. Moreover, while burdock root has traditional uses in herbal medicine for inflammatory conditions, the specific use of isolated arctiin for RA is not established in traditional medical systems. Therefore, while the compound shows promise in laboratory and animal models, the current evidence base to support its use in humans with RA is limited and insufficient for clinical recommendation.
Other ingredients used for Rheumatoid Arthritis
15,16-Dihydrotanshinone IAbies spectabilis
Abrus
Actaea spicata
adrenal cortex
Akebia
Alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-lipoic acid
alpha-pinene
alpinia galangal
amber
amentoflavone
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
anthocyanidins
anthocyanins
antler
apigenin
apocynin
Aralia
arctiin
arjunic acid
ashwagandha
astaxanthin
astragalin
baicalein
baicalin
barbasco
bee venom
Bergenia
Black Hellebore
Black willow
bogbean
borage oil
Boswellia
Boswellic Acid
bovine cartilage / glycosaminoglycan
C-phycocyanin
cannabidiol
carnosic acid
celery
Cetylated Fatty Acids
Chinese fleeceflower
Chinese pond turtle
chuchuhuasi
clematis
Clerodendrum phlomidis
cod liver oil
coenzyme Q10 (CoQ10)
cortisol
curcumin
cyanidin
d-alpha tocopherol
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
Dihomo-gamma-linolenic acid
docosahexaenoic Acid
dong quai root
DPA (docosapentaenoic acid)
eicosapentaenoic acid
Eicosatetraenoic acid
EPA (eicosapentaenoic acid)
evening primrose oil
evening primrose oil
fat liver oil
fisetin
fish protein
flavanols
flavones
Flemingia philippinensis
frankincense
fructoborate
Fumaria parviflora
gamma linolenic acid (GLA)
gamma tocopherol
genistein
Gentiana macrophylla
ginger
ginkgetin
green-lipped mussel
guelder rose
Gypenoside
Harpagoside
Hellebore
horse gram
hydroxytyrosol
Hyperoside
Jatropha macrantha
Kaempferol
krill oil
luteolin
madder
mangiferin
Marine fat
Methylsulfonylmethane (MSM)
Myricetin
Myristoleate
Nobiletin
omega-3 fatty acids
Osthole
Palmitoylethanolamide (PEA)
Phaeophyceae
phospholipids
Piper chaba
Polydatin
polyunsaturated fat
proteoglycans
Puerarin
Qin Jiao
resveratrol
rose hips
Salicin
Salmon Oil
Salvianolic acid
saponins
Schizochytrium
Schizochytrium Oil
Semecarpus anacardium
Shilajit
Silkmoth
Sinomenium acutum
slippery elm bark
smilax
Stearidonic acid
Sulforaphane
sulforaphane glucosinolate
Szechuan lovage
Tanshinone
Taxillus chinensis
teasel
turmeric
Uncaria
Urolithin A
Ursolic Acid
vitamin B6
vitamin C
vitamin D
vitamin D3
Watercress
white willow
Withanolides
Other health conditions supported by arctiin
Cancer (natural therapy for)Cancer (prevention)
Diabetes
Free Radical Damage
Inflammation
Inflammatory Bowel Disorders
Osteoporosis
Rheumatoid Arthritis