Evidence supporting the use of: Avocado Soy Unsaponifiables
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Avocado Soy Unsaponifiables (ASU) are natural extracts derived from avocado and soybean oils. Their primary use in rheumatology has centered on osteoarthritis rather than rheumatoid arthritis (RA). ASU has demonstrated mild anti-inflammatory properties and chondroprotective effects in laboratory and animal studies, and several randomized controlled trials have shown a modest benefit for symptom relief in osteoarthritis, particularly of the hip and knee. Its mechanism is thought to involve the inhibition of pro-inflammatory cytokines (such as IL-1 and TNF-α) and stimulation of collagen synthesis.

However, evidence supporting the use of ASU specifically in rheumatoid arthritis is limited. While the anti-inflammatory mechanisms theoretically could be relevant to RA, there are very few clinical trials investigating ASU in patients with this autoimmune disease. Most studies focus on osteoarthritis, and those that include RA patients are small or inconclusive. Systematic reviews and major rheumatology guidelines do not currently recommend ASU for RA management. Therefore, while there is a scientific rationale and some preclinical evidence, robust clinical validation in RA is lacking.

In summary, ASU is used in joint health supplements based on its effects in osteoarthritis, and the extrapolation to RA is not strongly supported by high-quality evidence. Its use in RA can be considered experimental, with a low overall evidence rating.

More about Avocado Soy Unsaponifiables
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Other health conditions supported by Avocado Soy Unsaponifiables

Arthritis
Cartilage Damage
Inflammation
Osteoporosis
Rheumatoid Arthritis

Products containing Avocado Soy Unsaponifiables

We currently have no products on Vitabase that contain this ingredient.