Evidence supporting the use of: Carnosic acid
For the health condition: Rheumatoid Arthritis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Carnosic acid, a major phenolic diterpene found in rosemary (Rosmarinus officinalis), has been investigated in preclinical studies for its anti-inflammatory and antioxidant properties, which are relevant to conditions like rheumatoid arthritis (RA). Several in vitro and animal model studies have demonstrated that carnosic acid can inhibit pro-inflammatory cytokines (such as TNF-α and IL-6), suppress NF-κB activation, and reduce oxidative stress markers—all of which play roles in the pathogenesis of RA. For example, studies in collagen-induced arthritis models in rodents have shown that carnosic acid administration can mitigate joint inflammation and tissue destruction. However, these findings are limited to laboratory and animal research; there is currently a lack of clinical trials or robust human studies directly evaluating carnosic acid’s efficacy for RA patients. While the mechanistic rationale is scientifically supported and the preclinical evidence is promising, the absence of clinical data means that its use in humans is not yet validated. Thus, carnosic acid’s application for RA is supported by early-stage scientific evidence, but more research—especially well-designed human clinical trials—is needed to determine its therapeutic potential and safety in this context.

More about Carnosic acid
More about Rheumatoid Arthritis

Products containing Carnosic acid

We currently have no products on Vitabase that contain this ingredient.