Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Coenzyme Q10 (CoQ10) is used to support the management of rheumatoid arthritis (RA), primarily based on emerging scientific evidence rather than longstanding traditional use. CoQ10 is a lipid-soluble antioxidant and a key component of the mitochondrial electron transport chain, playing a crucial role in cellular energy production and reducing oxidative stress. In the context of RA, which is a chronic inflammatory autoimmune disease, oxidative stress is known to contribute to joint damage and inflammation.

A limited number of clinical studies have investigated the role of CoQ10 in RA. For example, a 2015 randomized controlled trial published in the journal Clinical and Experimental Rheumatology found that RA patients who supplemented with CoQ10 (100 mg/day for 2 months) showed significant reductions in inflammatory markers such as TNF-α and IL-6, as well as improvements in disease activity scores, compared to placebo. Another small study reported improvements in oxidative stress parameters among RA patients who took CoQ10.

However, the overall body of evidence remains modest, with relatively few high-quality clinical trials and small sample sizes. Systematic reviews note that while CoQ10’s antioxidant and anti-inflammatory properties are promising, more robust, large-scale studies are needed to confirm its efficacy and establish dosing guidelines. In summary, scientific rationale exists for CoQ10 use in RA, but evidence strength is currently low to moderate (rated 2/5).

More about coenzyme Q10 (CoQ10)
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

Other health conditions supported by coenzyme Q10 (CoQ10)

Products containing coenzyme Q10 (CoQ10)

Pure Encapsulations Athletic Nutrients
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Douglas Laboratories Co-Enzyme Q10 Softgel
Douglas Laboratories Coenzyme Q-10 with Lipoic Acid
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Pure Encapsulations CoQ10 120 mg
Pure Encapsulations CoQ10 120 mg
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Pure Encapsulations CoQ10 30 mg
Pure Encapsulations CoQ10 500 mg
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Thorne CoQ10 Q-Best 100
Metagenics CoQ10 ST®-100 mg
Metagenics CoQ10 ST-100 mg
Metagenics CoQ10 ST-200 mg
Integrative Therapeutics Detoxication Factors
Integrative Therapeutics Detoxication Factors
Pure Encapsulations Energize Plus™ Pure Pack
Pure Encapsulations Hair/Skin/Nails Ultra
Thorne Heart Health Complex Q-10 Plus
Integrative Therapeutics K-PAX MitoNutrients
Vitabase Life's Essentials Plus
Designs For Health Mito-NR™
Pure Encapsulations Mitochondria-ATP
Designs For Health Mitochondrial NRG™
Pure Encapsulations NeuroMood Pure Pack
Metagenics NutraGems® CoQ10 300
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Thorne Omega-3 w/ CoQ10
Thorne Ovarian Care
Integrative Therapeutics ProThrivers Wellness Flav Complex
Pure Encapsulations PureGenomics® UltraMultivitamin
Designs For Health Q-Evail® 100
Designs For Health Q-Evail® 200
Pure Encapsulations Q-Gel® (Hydrosoluble™ CoQ10) 100 mg
Thorne Red Yeast Rice + CoQ10 Choleast
Pure Encapsulations Renual
Pure Encapsulations RevitalAge™ Nerve
Pure Encapsulations RevitalAge™ Ultra
Designs For Health RYR Synergy™
Pure Encapsulations SR-CoQ10 with PQQ
Vitabase Super Fat Burner
Pure Encapsulations Ubiquinol-QH 100 mg
Pure Encapsulations Ubiquinol-QH 200 mg
Pure Encapsulations Ubiquinol VESIsorb®
Integrative Therapeutics UBQH 100 mg
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Douglas Laboratories Ultra Preventive One Daily
Pure Encapsulations Ultra Pure Pack
Pure Encapsulations UltraDetox 10-Day Pure Pack
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Metagenics Wellness Essentials Brain Health Daily Packs