Evidence supporting the use of: Cortisol
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Cortisol, in the form of synthetic corticosteroids (such as prednisone or hydrocortisone), is widely used in the management of Rheumatoid Arthritis (RA) due to robust scientific evidence. Cortisol is a glucocorticoid hormone naturally produced by the adrenal cortex, and its synthetic analogues possess potent anti-inflammatory and immunosuppressive properties. In RA, chronic inflammation caused by autoimmune activity leads to joint damage and systemic symptoms. Corticosteroids suppress this inflammation by inhibiting multiple inflammatory pathways, including cytokine production and leukocyte migration.

Randomized controlled trials and decades of clinical use have consistently demonstrated that corticosteroids rapidly reduce pain, swelling, and stiffness in patients with active RA. They are often used for initial symptom control or as a "bridge therapy" while waiting for disease-modifying antirheumatic drugs (DMARDs) to take effect. Additionally, corticosteroids can be administered orally, intravenously, or by intra-articular injection.

However, long-term use is limited due to significant side effects, including osteoporosis, diabetes, hypertension, and increased infection risk. As a result, clinical guidelines recommend using the lowest effective dose for the shortest possible duration. The use of corticosteroids in RA is supported by major rheumatology organizations and is considered an evidence-based practice.

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Products containing Cortisol

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