Evidence supporting the use of: Curcumin
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Curcumin, the main bioactive compound in turmeric (Curcuma longa), has been traditionally used in Ayurvedic and Chinese medicine for inflammatory conditions, including arthritis. In recent years, its use for supporting or treating Rheumatoid Arthritis (RA) has garnered scientific interest. Several preclinical studies have demonstrated curcumin’s anti-inflammatory and immunomodulatory effects, such as inhibition of nuclear factor-kappa B (NF-κB) and downregulation of inflammatory cytokines like TNF-α, IL-6, and IL-1β, all of which play roles in RA pathogenesis.

A number of small clinical trials have evaluated curcumin (often in enhanced-bioavailability formulations) in patients with RA. For example, a 2012 randomized pilot study by Chandran and Goel found that curcumin supplementation significantly reduced Disease Activity Score (DAS28) and joint tenderness/swelling compared to a standard anti-inflammatory drug, and with fewer side effects. Other studies and systematic reviews have suggested that curcumin may help reduce symptoms such as pain and swelling, although limitations include small sample sizes, short study durations, and heterogeneity in curcumin formulations and dosages.

Overall, while curcumin use for RA has traditional roots, there is moderate scientific evidence supporting its adjunctive benefit in reducing RA symptoms, with a favorable safety profile. However, more large-scale, high-quality randomized controlled trials are needed to establish its efficacy and optimal dosing in RA treatment.

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