Evidence supporting the use of: Cyanidin
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cyanidin is a type of anthocyanin, a flavonoid pigment found in various fruits and vegetables such as berries and red cabbage. Its use in supporting or treating rheumatoid arthritis (RA) is justified primarily by scientific interest rather than long-standing traditional use. Several preclinical studies have investigated the anti-inflammatory and antioxidant properties of cyanidin and related anthocyanins. These studies, conducted mostly in vitro or in animal models, indicate that cyanidin can inhibit the production of pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6), suppress oxidative stress, and potentially reduce joint inflammation and cartilage degradation—all of which are relevant to RA pathophysiology. For example, research published in Food & Function (2018) and Journal of Nutritional Biochemistry (2013) has demonstrated that cyanidin can attenuate inflammatory responses and oxidative damage in animal models of arthritis. However, there is a lack of robust clinical trials in humans directly examining cyanidin supplementation in RA patients. The majority of available data are limited to cell culture studies and animal experiments, which provide a scientific rationale for further investigation but do not constitute strong clinical evidence. Overall, while there is scientific validation at the preclinical level suggesting potential benefits of cyanidin in RA, evidence from human studies is lacking. Thus, the current evidence supporting cyanidin for RA is preliminary and rates as low to moderate (2 out of 5).

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