Evidence supporting the use of: DHA (Docosahexaenoic Acid)
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHA (Docosahexaenoic Acid) is an omega-3 polyunsaturated fatty acid found primarily in fish oils. There is some scientific evidence supporting the use of omega-3 fatty acids, including DHA, to help manage symptoms of Rheumatoid Arthritis (RA), though most studies focus on combined supplements of EPA (eicosapentaenoic acid) and DHA, rather than DHA alone. Research indicates that omega-3 fatty acids have anti-inflammatory effects, which may help reduce joint pain, stiffness, and swelling in RA patients. Several randomized controlled trials and meta-analyses suggest a modest benefit of fish oil (rich in both EPA and DHA) supplementation in reducing disease activity and the need for NSAIDs in RA patients. However, the specific role of DHA, as distinct from EPA, is less well defined, and most benefits are attributed to the overall omega-3 content rather than DHA specifically.

Current guidelines from rheumatology organizations do not recommend DHA or omega-3 fatty acids as a primary or sole therapy, but acknowledge their potential as adjuncts to conventional treatment due to their favorable safety profile and possible symptom relief. Overall, while there is some scientific support for DHA (usually in combination with EPA) in RA, the evidence is not robust enough for strong clinical recommendations, and more research is needed to clarify DHA’s unique role.

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