Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diallyl disulfide (DADS) is an organosulfur compound derived primarily from garlic (Allium sativum). Its use for supporting Rheumatoid Arthritis (RA) is justified by preliminary scientific research, though robust clinical evidence is limited, and it is not a mainstream or fully established therapy. Experimental studies—primarily in animal models and in vitro—suggest that DADS possesses anti-inflammatory and immunomodulatory properties. For instance, DADS has been shown to inhibit the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, which are central to RA pathogenesis. Additionally, DADS may suppress the activation of nuclear factor kappa B (NF-κB), a key transcription factor involved in inflammation, and reduce oxidative stress by enhancing antioxidant enzyme activities.

However, the majority of evidence comes from preclinical studies. In rodent models of arthritis, DADS administration has resulted in reduced joint swelling, decreased inflammatory cell infiltration, and lower levels of inflammatory mediators. Despite these promising findings, there is a lack of high-quality human clinical trials specifically evaluating DADS for RA. Most human data pertains to garlic extracts in general, and not to isolated DADS. As such, while scientific rationale and some supportive data exist, the evidence base is not strong enough to fully endorse DADS as a treatment for RA.

Further clinical research is needed to determine its efficacy, safety, appropriate dosing, and mechanism of action in humans with Rheumatoid Arthritis.

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Designs For Health Allicillin™