Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dihomo-gamma-linolenic acid (DGLA) is an omega-6 fatty acid that serves as an intermediate in the metabolism of linoleic acid and gamma-linolenic acid (GLA). Some scientific interest exists regarding its potential anti-inflammatory effects, particularly in conditions like rheumatoid arthritis (RA). DGLA can be converted to anti-inflammatory eicosanoids, such as prostaglandin E1 (PGE1), which is thought to modulate immune response and decrease inflammation.

However, direct clinical evidence supporting the use of DGLA supplementation specifically for RA is limited. Most human studies have focused on GLA-containing oils (such as evening primrose oil or borage oil), which are metabolized to DGLA in the body. Some of these studies have shown modest improvements in symptoms of RA, but results are inconsistent and sample sizes are often small. Furthermore, the benefit is generally attributed to the downstream anti-inflammatory effects of DGLA, rather than robust direct evidence for DGLA itself.

Major clinical guidelines do not currently endorse DGLA (or GLA) as a standard therapy for RA, and systematic reviews conclude that while there may be some anti-inflammatory potential, the evidence is not strong enough to firmly recommend its use. Thus, while there is a scientific rationale and some limited supporting data, the evidence base remains modest (rated 2/5).

More about Dihomo-gamma-linolenic acid
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

15,16-Dihydrotanshinone I
Abies spectabilis
Abrus
Actaea spicata
adrenal cortex
Akebia
Alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-lipoic acid
alpha-pinene
alpinia galangal
amber
amentoflavone
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
anthocyanidins
anthocyanins
antler
apigenin
apocynin
Aralia
arctiin
arjunic acid
ashwagandha
astaxanthin
astragalin
baicalein
baicalin
barbasco
bee venom
Bergenia
Black Hellebore
Black willow
bogbean
borage oil
Boswellia
Boswellic Acid
bovine cartilage / glycosaminoglycan
C-phycocyanin
cannabidiol
carnosic acid
celery
Cetylated Fatty Acids
Chinese fleeceflower
Chinese pond turtle
chuchuhuasi
clematis
Clerodendrum phlomidis
cod liver oil
coenzyme Q10 (CoQ10)
cortisol
curcumin
cyanidin
d-alpha tocopherol
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
Dihomo-gamma-linolenic acid
docosahexaenoic Acid
dong quai root
DPA (docosapentaenoic acid)
eicosapentaenoic acid
Eicosatetraenoic acid
EPA (eicosapentaenoic acid)
evening primrose oil
evening primrose oil
fat liver oil
fisetin
fish protein
flavanols
flavones
Flemingia philippinensis
frankincense
fructoborate
Fumaria parviflora
gamma linolenic acid (GLA)
gamma tocopherol
genistein
Gentiana macrophylla
ginger
ginkgetin
green-lipped mussel
guelder rose
Gypenoside
Harpagoside
Hellebore
horse gram
hydroxytyrosol
Hyperoside
Jatropha macrantha
Kaempferol
krill oil
luteolin
madder
mangiferin
Marine fat
Methylsulfonylmethane (MSM)
Myricetin
Myristoleate
Nobiletin
omega-3 fatty acids
Osthole
Palmitoylethanolamide (PEA)
Phaeophyceae
phospholipids
Piper chaba
Polydatin
polyunsaturated fat
proteoglycans
Puerarin
Qin Jiao
resveratrol
rose hips
Salicin
Salmon Oil
Salvianolic acid
saponins
Schizochytrium
Schizochytrium Oil
Semecarpus anacardium
Shilajit
Silkmoth
Sinomenium acutum
slippery elm bark
smilax
Stearidonic acid
Sulforaphane
sulforaphane glucosinolate
Szechuan lovage
Tanshinone
Taxillus chinensis
teasel
turmeric
Uncaria
Urolithin A
Ursolic Acid
vitamin B6
vitamin C
vitamin D
vitamin D3
Watercress
white willow
Withanolides

Other health conditions supported by Dihomo-gamma-linolenic acid

Arthritis
Autoimmune Disorders
Inflammation
Rheumatoid Arthritis

Products containing Dihomo-gamma-linolenic acid

We currently have no products on Vitabase that contain this ingredient.