Evidence supporting the use of: European peony
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Paeonia lactiflora, known as European or Chinese peony, has a long history of use in traditional Chinese medicine (TCM) for treating autoimmune and inflammatory conditions, including rheumatoid arthritis (RA). The root is a key ingredient in the TCM formula "Tangkuei Decoction for Rheumatism" and in "Total Glucosides of Peony" (TGP), which is prescribed for RA and related disorders in China. Historical texts and modern TCM practitioners both cite its anti-inflammatory and immunomodulatory effects as rationales for use.

While there is some scientific research suggesting anti-inflammatory and immunosuppressive properties of peony extracts (especially paeoniflorin), the majority of the evidence comes from traditional use and clinical experience in China. A few randomized controlled trials and meta-analyses suggest that TGP may reduce disease activity and improve symptoms when combined with standard RA treatments, with fewer side effects. However, most studies are of moderate to low quality, often conducted in China, and may not meet rigorous international standards for clinical research.

In summary, European peony’s use for RA is primarily rooted in tradition, with some emerging scientific support, but the evidence is not yet robust or universally accepted. Peony preparations are not a standard therapy for RA in Western medicine.

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