Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Evening primrose oil (EPO) is sometimes used as a complementary treatment for rheumatoid arthritis (RA), primarily due to its content of gamma-linolenic acid (GLA), an omega-6 fatty acid with purported anti-inflammatory properties. The theoretical basis is that GLA can be converted in the body to prostaglandin E1, a substance that may help reduce inflammation. Several small randomized controlled trials have explored the effects of EPO or GLA supplements in people with RA. Some of these studies have reported modest improvements in symptoms such as joint pain, morning stiffness, and overall disease activity compared to placebo. However, the evidence is mixed: other studies have found minimal or no benefit, and meta-analyses generally conclude that the effect size is small and of questionable clinical significance. The American College of Rheumatology does not recommend EPO as a standard therapy for RA due to insufficient and inconsistent evidence. Safety appears acceptable at typical doses, but side effects such as gastrointestinal upset and potential interactions with anticoagulant medications have been reported. In summary, while there is a scientific rationale and limited clinical data suggesting a potential benefit of evening primrose oil in RA, the overall quality and consistency of the evidence is low, and it is not considered a primary or well-supported treatment for this condition.

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Pure Encapsulations E.P.O. 500 mg
Pure Encapsulations E.P.O. 500 mg