Evidence supporting the use of: Flavones
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavones are a class of polyphenolic compounds found in many plants, including fruits, vegetables, and medicinal herbs. Their use in the context of rheumatoid arthritis (RA) is primarily supported by preclinical scientific research rather than longstanding traditional use. Several in vitro (cell culture) and animal studies have shown that flavones—such as apigenin, luteolin, and baicalein—possess anti-inflammatory and immunomodulatory properties. These compounds have been demonstrated to inhibit pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6) and reduce oxidative stress, both of which play key roles in the pathogenesis of RA. For instance, studies involving animal models of RA (such as collagen-induced arthritis in mice) have reported that flavones can reduce joint swelling, cartilage degradation, and inflammatory cell infiltration. Mechanistically, flavones appear to downregulate the NF-κB signaling pathway, which is central to inflammation in RA. However, clinical evidence in humans is very limited, with only a few small-scale studies or pilot trials investigating flavones directly in RA patients. In summary, while there is promising preclinical evidence to suggest that flavones may have beneficial effects in RA, robust clinical trials are lacking. Accordingly, the evidence rating is moderate-low (2/5), reflecting the gap between experimental findings and validated therapeutic use in humans.

More about flavones
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

15,16-Dihydrotanshinone I
Abies spectabilis
Abrus
Actaea spicata
adrenal cortex
Akebia
Alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-lipoic acid
alpha-pinene
alpinia galangal
amber
amentoflavone
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
anthocyanidins
anthocyanins
antler
apigenin
apocynin
Aralia
arctiin
arjunic acid
ashwagandha
astaxanthin
astragalin
baicalein
baicalin
barbasco
bee venom
Bergenia
Black Hellebore
Black willow
bogbean
borage oil
Boswellia
Boswellic Acid
bovine cartilage / glycosaminoglycan
C-phycocyanin
cannabidiol
carnosic acid
celery
Cetylated Fatty Acids
Chinese fleeceflower
Chinese pond turtle
chuchuhuasi
clematis
Clerodendrum phlomidis
cod liver oil
coenzyme Q10 (CoQ10)
cortisol
curcumin
cyanidin
d-alpha tocopherol
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
Dihomo-gamma-linolenic acid
docosahexaenoic Acid
dong quai root
DPA (docosapentaenoic acid)
eicosapentaenoic acid
Eicosatetraenoic acid
EPA (eicosapentaenoic acid)
evening primrose oil
evening primrose oil
fat liver oil
fisetin
fish protein
flavanols
flavones
Flemingia philippinensis
frankincense
fructoborate
Fumaria parviflora
gamma linolenic acid (GLA)
gamma tocopherol
genistein
Gentiana macrophylla
ginger
ginkgetin
green-lipped mussel
guelder rose
Gypenoside
Harpagoside
Hellebore
horse gram
hydroxytyrosol
Hyperoside
Jatropha macrantha
Kaempferol
krill oil
luteolin
madder
mangiferin
Marine fat
Methylsulfonylmethane (MSM)
Myricetin
Myristoleate
Nobiletin
omega-3 fatty acids
Osthole
Palmitoylethanolamide (PEA)
Phaeophyceae
phospholipids
Piper chaba
Polydatin
polyunsaturated fat
proteoglycans
Puerarin
Qin Jiao
resveratrol
rose hips
Salicin
Salmon Oil
Salvianolic acid
saponins
Schizochytrium
Schizochytrium Oil
Semecarpus anacardium
Shilajit
Silkmoth
Sinomenium acutum
slippery elm bark
smilax
Stearidonic acid
Sulforaphane
sulforaphane glucosinolate
Szechuan lovage
Tanshinone
Taxillus chinensis
teasel
turmeric
Uncaria
Urolithin A
Ursolic Acid
vitamin B6
vitamin C
vitamin D
vitamin D3
Watercress
white willow
Withanolides

Products containing flavones

We currently have no products on Vitabase that contain this ingredient.