Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Gamma linolenic acid (GLA) is a polyunsaturated omega-6 fatty acid found in plant oils such as evening primrose, borage, and black currant seed oil. Its use in rheumatoid arthritis (RA) is primarily supported by scientific investigation rather than tradition. GLA is believed to exert anti-inflammatory effects by being converted in the body to dihomo-gamma-linolenic acid (DGLA), which can compete with arachidonic acid and reduce the synthesis of pro-inflammatory eicosanoids.

Several clinical studies and meta-analyses have evaluated GLA supplementation for RA. Some randomized controlled trials (RCTs) have reported modest improvements in joint pain, stiffness, and swelling with GLA supplementation compared to placebo. For example, a 1993 study published in Annals of Internal Medicine showed that patients receiving GLA experienced significant improvement in RA symptoms. However, other studies have found only minimal or inconsistent benefits. A 2011 Cochrane review concluded that while there is some evidence suggesting a small benefit, the overall quality of evidence is low, and the clinical significance remains uncertain.

GLA is not a mainstream therapy for RA, but it is sometimes used as an adjunct to conventional treatment due to its relatively favorable safety profile. Current guidelines do not universally recommend GLA, but it remains an area of interest for patients seeking complementary approaches. In summary, there is limited scientific validation for GLA in RA, and the supporting evidence is rated as weak to moderate (2 out of 5).

More about gamma linolenic acid (GLA)
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

Other health conditions supported by gamma linolenic acid (GLA)

Products containing gamma linolenic acid (GLA)

Vitabase Active Woman's Multi
Pure Encapsulations Black Currant Seed
Pure Encapsulations Black Currant Seed
Vitabase Complete Essential Fatty Acids
Pure Encapsulations EFA Essentials
Designs For Health GLA (Gamma-Linolenic Acid)
Metagenics OmegaGenics Evening Primrose Oil
Metagenics OmegaGenics GLA 240 mg
Designs For Health OmegAvail™ Synergy
Designs For Health OmegAvail™ Synergy
Vitabase Super Fat Burner
Douglas Laboratories Ultra G.L.A. Borage Oil
Douglas Laboratories Ultra G.L.A. Borage Oil
Pure Encapsulations VisionPro EPA/DHA/GLA
Pure Encapsulations VisionPro EPA/DHA/GLA