Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Genistein is an isoflavone primarily found in soy products and has been investigated for its potential anti-inflammatory and immunomodulatory effects, which are relevant to rheumatoid arthritis (RA). Preclinical studies, particularly in vitro and in animal models, have demonstrated that genistein can inhibit the production of pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6) and modulate immune cell function. Some studies suggest that genistein may block NF-κB signaling, a key pathway involved in the chronic inflammation seen in RA. Additionally, genistein’s antioxidant properties may help reduce oxidative stress in joint tissues.

However, clinical evidence supporting the use of genistein for RA in humans is limited. Few small-scale clinical trials have evaluated its efficacy directly in RA patients. Most available human data relate to its general anti-inflammatory actions or its use in menopausal symptoms and osteoporosis rather than RA specifically. Systematic reviews and meta-analyses have not established genistein as an effective standalone or adjunctive therapy for RA. Therefore, while there is a scientific rationale and promising preclinical data, robust clinical evidence is lacking, and its use for RA cannot be strongly recommended at this time.

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