Horse Gram (Macrotyloma uniflorum) has a long history of use in traditional Indian medicine systems, including Ayurveda and Siddha, where it is recommended for various ailments such as joint pain, inflammation, and specifically, conditions resembling rheumatoid arthritis (RA). Traditional texts describe its use as a "kaphahara" (reducing excess 'kapha' or phlegm) and as having properties believed to alleviate swelling and pain in the joints. Preparations including Horse Gram are sometimes prescribed as part of dietary management for patients with chronic inflammatory conditions.

From a scientific standpoint, there is very limited evidence directly linking Horse Gram to the management of rheumatoid arthritis. Some in vitro and animal studies suggest that Horse Gram contains phenolic compounds and antioxidants, which may have general anti-inflammatory effects. However, these studies are preliminary and do not specifically address RA or demonstrate clinical efficacy in humans. No large-scale, high-quality clinical trials are available to confirm its effectiveness in rheumatoid arthritis patients.

In summary, the use of Horse Gram for RA is primarily supported by traditional knowledge, with only low-level scientific evidence suggesting general anti-inflammatory potential. Its use in this context should be considered as complementary and not as a replacement for evidence-based medical therapies.