Evidence supporting the use of: Hyperoside
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hyperoside is a flavonoid glycoside found in various medicinal plants, such as Hypericum perforatum (St. John’s Wort), Crataegus species (hawthorn), and others. Recent preclinical studies have explored its potential anti-inflammatory and immunomodulatory effects, which are relevant to the pathogenesis of Rheumatoid Arthritis (RA). Several in vitro and animal studies suggest that hyperoside can inhibit the production of pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6), suppress the activation of NF-κB signaling pathways, and reduce oxidative stress in models of inflammatory diseases, including experimental arthritis in rodents.

For example, a 2020 study in Frontiers in Pharmacology demonstrated that hyperoside attenuated collagen-induced arthritis in mice by reducing joint inflammation and cartilage destruction, likely through suppression of inflammatory mediators and modulation of immune cell infiltration. Other laboratory studies have reported similar findings, indicating reduced joint swelling and improved histopathological scores in hyperoside-treated animals.

However, there is currently a lack of clinical trials in humans evaluating hyperoside’s efficacy or safety in the treatment of RA. Most supporting evidence is limited to experimental models, and the translation of these results to human disease remains uncertain. Thus, while there is some scientific rationale and preclinical support, clinical validation is lacking, and the overall evidence remains preliminary.

More about Hyperoside
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

15,16-Dihydrotanshinone I
Abies spectabilis
Abrus
Actaea spicata
adrenal cortex
Akebia
Alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-lipoic acid
alpha-pinene
alpinia galangal
amber
amentoflavone
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
anthocyanidins
anthocyanins
antler
apigenin
apocynin
Aralia
arctiin
arjunic acid
ashwagandha
astaxanthin
astragalin
baicalein
baicalin
barbasco
bee venom
Bergenia
Black Hellebore
Black willow
bogbean
borage oil
Boswellia
Boswellic Acid
bovine cartilage / glycosaminoglycan
C-phycocyanin
cannabidiol
carnosic acid
celery
Cetylated Fatty Acids
Chinese fleeceflower
Chinese pond turtle
chuchuhuasi
clematis
Clerodendrum phlomidis
cod liver oil
coenzyme Q10 (CoQ10)
cortisol
curcumin
cyanidin
d-alpha tocopherol
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
Dihomo-gamma-linolenic acid
docosahexaenoic Acid
dong quai root
DPA (docosapentaenoic acid)
eicosapentaenoic acid
Eicosatetraenoic acid
EPA (eicosapentaenoic acid)
evening primrose oil
evening primrose oil
fat liver oil
fisetin
fish protein
flavanols
flavones
Flemingia philippinensis
frankincense
fructoborate
Fumaria parviflora
gamma linolenic acid (GLA)
gamma tocopherol
genistein
Gentiana macrophylla
ginger
ginkgetin
green-lipped mussel
guelder rose
Gypenoside
Harpagoside
Hellebore
horse gram
hydroxytyrosol
Hyperoside
Jatropha macrantha
Kaempferol
krill oil
luteolin
madder
mangiferin
Marine fat
Methylsulfonylmethane (MSM)
Myricetin
Myristoleate
Nobiletin
omega-3 fatty acids
Osthole
Palmitoylethanolamide (PEA)
Phaeophyceae
phospholipids
Piper chaba
Polydatin
polyunsaturated fat
proteoglycans
Puerarin
Qin Jiao
resveratrol
rose hips
Salicin
Salmon Oil
Salvianolic acid
saponins
Schizochytrium
Schizochytrium Oil
Semecarpus anacardium
Shilajit
Silkmoth
Sinomenium acutum
slippery elm bark
smilax
Stearidonic acid
Sulforaphane
sulforaphane glucosinolate
Szechuan lovage
Tanshinone
Taxillus chinensis
teasel
turmeric
Uncaria
Urolithin A
Ursolic Acid
vitamin B6
vitamin C
vitamin D
vitamin D3
Watercress
white willow
Withanolides

Products containing Hyperoside

We currently have no products on Vitabase that contain this ingredient.