Evidence supporting the use of: Methylsulfonylmethane
For the health condition: Rheumatoid Arthritis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Methylsulfonylmethane (MSM) is a popular dietary supplement often marketed for joint health and the management of inflammatory conditions such as rheumatoid arthritis (RA). The rationale for its use is primarily based on its proposed anti-inflammatory properties, as MSM is thought to inhibit inflammatory cytokines and oxidative stress. However, scientific evidence supporting the efficacy of MSM specifically for RA is minimal and of low quality.

Most of the available studies involving MSM have focused on osteoarthritis, not RA. For osteoarthritis, a few small randomized controlled trials suggest MSM may provide modest improvements in pain and physical function. In contrast, clinical evidence for MSM in RA is scarce. Only a handful of small and methodologically limited studies have examined MSM in RA patients, and results have been inconclusive or have not demonstrated significant benefit over placebo. Major medical organizations and rheumatology guidelines do not currently recommend MSM for RA treatment.

To date, there is no substantial scientific validation for the use of MSM in rheumatoid arthritis. Its popularity as a supplement for RA is mainly extrapolated from its use in other joint conditions and from animal or in vitro studies. Further high-quality research is necessary to determine if MSM has any meaningful therapeutic role in RA.

More about Methylsulfonylmethane
More about Rheumatoid Arthritis

Products containing Methylsulfonylmethane

We currently have no products on Vitabase that contain this ingredient.