Evidence supporting the use of: Polydatin
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Synopsis of Evidence Supporting Polydatin for Rheumatoid Arthritis

Polydatin, a natural glycoside of resveratrol found in Polygonum cuspidatum and other plants, has attracted scientific interest for its anti-inflammatory and antioxidant properties. Several preclinical studies have investigated its effects in models of rheumatoid arthritis (RA). For example, animal studies have shown that polydatin administration can reduce joint inflammation, cartilage destruction, and expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in collagen-induced arthritis models in mice. Mechanistically, it is believed to exert these effects through inhibition of the NF-κB signaling pathway, modulation of oxidative stress, and suppression of inflammatory mediators.

However, the evidence is currently limited to in vitro experiments and animal models; there are no published clinical trials evaluating the efficacy or safety of polydatin in human patients with RA. While these findings are promising and suggest a potential therapeutic role, the absence of human data means that its use cannot yet be recommended as standard therapy. Most existing research has been published in the last decade and is exploratory in nature. Therefore, the evidence supporting the use of polydatin in RA can be considered preliminary (rated 2 out of 5), pending further clinical research.

More about Polydatin
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

15,16-Dihydrotanshinone I
Abies spectabilis
Abrus
Actaea spicata
adrenal cortex
Akebia
Alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-lipoic acid
alpha-pinene
alpinia galangal
amber
amentoflavone
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
anthocyanidins
anthocyanins
antler
apigenin
apocynin
Aralia
arctiin
arjunic acid
ashwagandha
astaxanthin
astragalin
baicalein
baicalin
barbasco
bee venom
Bergenia
Black Hellebore
Black willow
bogbean
borage oil
Boswellia
Boswellic Acid
bovine cartilage / glycosaminoglycan
C-phycocyanin
cannabidiol
carnosic acid
celery
Cetylated Fatty Acids
Chinese fleeceflower
Chinese pond turtle
chuchuhuasi
clematis
Clerodendrum phlomidis
cod liver oil
coenzyme Q10 (CoQ10)
cortisol
curcumin
cyanidin
d-alpha tocopherol
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
Dihomo-gamma-linolenic acid
docosahexaenoic Acid
dong quai root
DPA (docosapentaenoic acid)
eicosapentaenoic acid
Eicosatetraenoic acid
EPA (eicosapentaenoic acid)
evening primrose oil
evening primrose oil
fat liver oil
fisetin
fish protein
flavanols
flavones
Flemingia philippinensis
frankincense
fructoborate
Fumaria parviflora
gamma linolenic acid (GLA)
gamma tocopherol
genistein
Gentiana macrophylla
ginger
ginkgetin
green-lipped mussel
guelder rose
Gypenoside
Harpagoside
Hellebore
horse gram
hydroxytyrosol
Hyperoside
Jatropha macrantha
Kaempferol
krill oil
luteolin
madder
mangiferin
Marine fat
Methylsulfonylmethane (MSM)
Myricetin
Myristoleate
Nobiletin
omega-3 fatty acids
Osthole
Palmitoylethanolamide (PEA)
Phaeophyceae
phospholipids
Piper chaba
Polydatin
polyunsaturated fat
proteoglycans
Puerarin
Qin Jiao
resveratrol
rose hips
Salicin
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saponins
Schizochytrium
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Semecarpus anacardium
Shilajit
Silkmoth
Sinomenium acutum
slippery elm bark
smilax
Stearidonic acid
Sulforaphane
sulforaphane glucosinolate
Szechuan lovage
Tanshinone
Taxillus chinensis
teasel
turmeric
Uncaria
Urolithin A
Ursolic Acid
vitamin B6
vitamin C
vitamin D
vitamin D3
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white willow
Withanolides

Products containing Polydatin

We currently have no products on Vitabase that contain this ingredient.