Evidence supporting the use of: Puerarin
For the health condition: Rheumatoid Arthritis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Puerarin is an isoflavone derived from the root of Pueraria lobata (kudzu), a traditional Chinese medicinal plant. Its use in rheumatoid arthritis (RA) is not deeply rooted in historical or traditional medicine for this specific condition, but rather has emerged from scientific investigation into its pharmacological properties. Preclinical studies, primarily in cell cultures and animal models, have shown that puerarin possesses anti-inflammatory and immunomodulatory effects. For instance, research published in peer-reviewed journals has reported that puerarin can inhibit the production of pro-inflammatory cytokines (such as TNF-α and IL-1β), suppress the activation of NF-κB signaling pathways, and reduce synovial hyperplasia—processes relevant to the pathogenesis of RA.

Some studies have demonstrated that puerarin can alleviate joint swelling and tissue damage in collagen-induced arthritis models in rodents, which are commonly used to mimic human RA. These findings suggest a potential therapeutic effect. However, the evidence is limited primarily to preclinical research. There are few, if any, well-designed clinical trials in humans evaluating puerarin's efficacy or safety in the management of RA. As a result, while there is a scientific rationale and some experimental support, the clinical evidence is insufficient, and puerarin should not be considered a proven or standard therapy for RA.

More about Puerarin
More about Rheumatoid Arthritis

Products containing Puerarin

We currently have no products on Vitabase that contain this ingredient.