Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol, a polyphenolic compound found in grapes, berries, and peanuts, has attracted scientific interest for its anti-inflammatory and antioxidant properties. Its application in rheumatoid arthritis (RA) is primarily based on preclinical and limited clinical evidence rather than traditional use. In animal models of RA, resveratrol has demonstrated the ability to reduce joint inflammation, inhibit pro-inflammatory cytokines (such as TNF-α and IL-1β), and protect cartilage from degradation. The underlying mechanisms are thought to involve the suppression of NF-κB signaling and the activation of SIRT1, both of which regulate inflammatory pathways.

Some small human studies and pilot clinical trials have suggested potential benefits of resveratrol as an adjunct therapy in RA patients, such as reduced inflammatory markers and modest improvements in symptoms. However, these studies are often limited by small sample sizes, short duration, and methodological concerns.

As of 2024, there is not enough high-quality clinical evidence to strongly support the routine use of resveratrol in RA management. Most guidelines do not mention it, and it is not a mainstream treatment. However, ongoing research continues to investigate its potential as a complementary therapy.

In summary, while there is scientific rationale and early research supporting the possible benefit of resveratrol for RA, the current level of evidence is low to moderate (rated 2/5), and its use should be considered experimental pending further clinical validation.

More about resveratrol
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

Other health conditions supported by resveratrol

Products containing resveratrol

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Thorne L-Arginine Plus Perfusia Plus
Pure Encapsulations Memory Pro
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Designs For Health Primal Multi™
Pure Encapsulations Renual
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Metagenics Wellness Essentials Active Daily Packs
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Metagenics Wellness Essentials® Daily Packs
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