Evidence supporting the use of: Squid Oil
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Squid oil is a marine oil rich in omega-3 polyunsaturated fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—the same principal active components found in fish oil. The use of omega-3 fatty acids for rheumatoid arthritis (RA) is scientifically investigated, with several clinical trials and meta-analyses indicating that supplementation can reduce joint tenderness, morning stiffness, and overall disease activity in RA patients when used alongside conventional therapies. The mechanism is thought to involve the anti-inflammatory properties of EPA and DHA, which modulate the production of pro-inflammatory eicosanoids and cytokines.

While fish oil is more commonly studied and used, squid oil is considered an alternative marine source of omega-3s, with some research showing comparable bioavailability. However, direct clinical studies of squid oil specifically in the context of RA are limited, and most available evidence is extrapolated from broader omega-3 studies. The overall quality of evidence supporting omega-3 supplementation in RA is moderate, with benefits being modest and most pronounced in patients with high baseline inflammation or who consume low dietary omega-3s.

In summary, while squid oil itself is less directly studied, the omega-3 fatty acids it provides are supported by a moderate level of scientific evidence for adjunctive use in rheumatoid arthritis management. It should not replace standard medical therapy but may provide additional benefit.

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