Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Stearidonic acid (SDA) is an omega-3 fatty acid found in certain plant oils, such as echium and blackcurrant seed oil. Its use for rheumatoid arthritis (RA) is rooted in the broader concept that omega-3 fatty acids have anti-inflammatory effects, which may be beneficial in managing autoimmune and inflammatory conditions like RA. SDA is a metabolic precursor to eicosapentaenoic acid (EPA), a marine-derived omega-3 with well-documented anti-inflammatory effects and some evidence for symptomatic benefit in RA.

However, the direct evidence for SDA itself in the treatment or support of RA is limited. Most studies focus on EPA and docosahexaenoic acid (DHA) from fish oils, rather than plant-derived SDA. Some small clinical trials and mechanistic studies have shown that SDA supplementation can increase EPA levels in the body, but there is a lack of robust clinical trials directly assessing the effects of SDA on RA outcomes such as pain, swelling, or disease activity. Reviews and expert opinions consider the theoretical rationale plausible but emphasize the need for more targeted research.

In summary, while there is a scientific rationale for considering SDA as a supportive treatment for RA—based on its conversion to EPA and the known benefits of omega-3s—direct evidence is weak, and its effectiveness for RA specifically is not well established. The evidence rating is therefore 2 out of 5, reflecting preclinical data and mechanistic plausibility, but insufficient direct clinical validation.

More about Stearidonic acid
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

adrenal cortex
Alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-pinene
anthocyanins
ashwagandha
astaxanthin
borage oil
celery
coenzyme Q10 (CoQ10)
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
dong quai root
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
evening primrose oil
fisetin
fish protein
gamma linolenic acid (GLA)
gamma tocopherol
genistein
ginger
green lipped mussel
krill oil
luteolin
methylsulfonylmethane (MSM)
myristoleate
omega-3 fatty acids
phospholipids
resveratrol
rose hips
sardines
slippery elm bark
sulforaphane glucosinolate
Urolithin A
vitamin B6
vitamin C
vitamin D
vitamin D3
watercress
white willow
alpinia galangal
smilax
fumaria parviflora
Szechuan lovage
amber
teasel
guelder rose
gentiana macrophylla
Abies spectabilis
AMP-activated protein kinase (AMPK)
clematis
15,16-Dihydrotanshinone I
Aralia
Akebia
Antler
Apigenin
Abrus
Andrographolide
Amentoflavone
Alpha-Lipoic Acid
anthocyanidins
Ampelopsin
Actaea spicata
Arjunic Acid
Apocynin
Arctiin
Astragalin
Boswellic Acid
Baicalein
Bogbean
Boswellia
Black willow
Barbasco
bovine cartilage / glycosaminoglycan
Baicalin
Black Hellebore
Bee venom
Bergenia
Cod Liver Oil
Cortisol
Clerodendrum phlomidis
Cyanidin
Chinese Fleeceflower
Chinese Pond Turtle
Chuchuhuasi
Cetylated Fatty Acids
C-Phycocyanin
Cannabidiol
Carnosic acid
Docosahexaenoic Acid
Dihomo-gamma-linolenic acid
Eicosatetraenoic acid
Eicosapentaenoic Acid
Evening Primrose Oil
Fat liver oil
Fructoborate
Flemingia philippinensis
Frankincense
Flavanols
Flavones
Ginkgetin
Gypenoside
Horse Gram
Hyperoside
Hellebore
Hydroxytyrosol
Harpagoside
Jatropha macrantha
Kaempferol
Mangiferin
Myricetin
Madder
Marine fat
Nobiletin
Osthole
Puerarin
Piper chaba
Phaeophyceae
Proteoglycans
Polydatin
Polyunsaturated Fat
Palmitoylethanolamide (PEA)
Qin Jiao
Silkmoth
Schizochytrium Oil
Schizochytrium
Salicin
Salmon Oil
Salvianolic acid
Sinomenium acutum
Semecarpus anacardium
saponins
Shilajit
Stearidonic acid
Sulforaphane
Taxillus chinensis
Tanshinone
Uncaria
Ursolic Acid
Withanolides

Other health conditions supported by Stearidonic acid

Arthritis
Cardiovascular Disease
Cholesterol (high)
Inflammation
Rheumatoid Arthritis
Triglycerides (high)

Products containing Stearidonic acid

We currently have no products on Vitabase that contain this ingredient.