Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Stearidonic acid (SDA) is an omega-3 fatty acid found in certain plant oils, such as echium and blackcurrant seed oil. Its use for rheumatoid arthritis (RA) is rooted in the broader concept that omega-3 fatty acids have anti-inflammatory effects, which may be beneficial in managing autoimmune and inflammatory conditions like RA. SDA is a metabolic precursor to eicosapentaenoic acid (EPA), a marine-derived omega-3 with well-documented anti-inflammatory effects and some evidence for symptomatic benefit in RA.

However, the direct evidence for SDA itself in the treatment or support of RA is limited. Most studies focus on EPA and docosahexaenoic acid (DHA) from fish oils, rather than plant-derived SDA. Some small clinical trials and mechanistic studies have shown that SDA supplementation can increase EPA levels in the body, but there is a lack of robust clinical trials directly assessing the effects of SDA on RA outcomes such as pain, swelling, or disease activity. Reviews and expert opinions consider the theoretical rationale plausible but emphasize the need for more targeted research.

In summary, while there is a scientific rationale for considering SDA as a supportive treatment for RA—based on its conversion to EPA and the known benefits of omega-3s—direct evidence is weak, and its effectiveness for RA specifically is not well established. The evidence rating is therefore 2 out of 5, reflecting preclinical data and mechanistic plausibility, but insufficient direct clinical validation.

More about Stearidonic acid
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

15,16-Dihydrotanshinone I
Abies spectabilis
Abrus
Actaea spicata
adrenal cortex
Akebia
Alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-lipoic acid
alpha-pinene
alpinia galangal
amber
amentoflavone
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
anthocyanidins
anthocyanins
antler
apigenin
apocynin
Aralia
arctiin
arjunic acid
ashwagandha
astaxanthin
astragalin
baicalein
baicalin
barbasco
bee venom
Bergenia
Black Hellebore
Black willow
bogbean
borage oil
Boswellia
Boswellic Acid
bovine cartilage / glycosaminoglycan
C-phycocyanin
cannabidiol
carnosic acid
celery
Cetylated Fatty Acids
Chinese fleeceflower
Chinese pond turtle
chuchuhuasi
clematis
Clerodendrum phlomidis
cod liver oil
coenzyme Q10 (CoQ10)
cortisol
curcumin
cyanidin
d-alpha tocopherol
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
Dihomo-gamma-linolenic acid
docosahexaenoic Acid
dong quai root
DPA (docosapentaenoic acid)
eicosapentaenoic acid
Eicosatetraenoic acid
EPA (eicosapentaenoic acid)
evening primrose oil
evening primrose oil
fat liver oil
fisetin
fish protein
flavanols
flavones
Flemingia philippinensis
frankincense
fructoborate
Fumaria parviflora
gamma linolenic acid (GLA)
gamma tocopherol
genistein
Gentiana macrophylla
ginger
ginkgetin
green-lipped mussel
guelder rose
Gypenoside
Harpagoside
Hellebore
horse gram
hydroxytyrosol
Hyperoside
Jatropha macrantha
Kaempferol
krill oil
luteolin
madder
mangiferin
Marine fat
Methylsulfonylmethane (MSM)
Myricetin
Myristoleate
Nobiletin
omega-3 fatty acids
Osthole
Palmitoylethanolamide (PEA)
Phaeophyceae
phospholipids
Piper chaba
Polydatin
polyunsaturated fat
proteoglycans
Puerarin
Qin Jiao
resveratrol
rose hips
Salicin
Salmon Oil
Salvianolic acid
saponins
Schizochytrium
Schizochytrium Oil
Semecarpus anacardium
Shilajit
Silkmoth
Sinomenium acutum
slippery elm bark
smilax
Stearidonic acid
Sulforaphane
sulforaphane glucosinolate
Szechuan lovage
Tanshinone
Taxillus chinensis
teasel
turmeric
Uncaria
Urolithin A
Ursolic Acid
vitamin B6
vitamin C
vitamin D
vitamin D3
Watercress
white willow
Withanolides

Other health conditions supported by Stearidonic acid

Arthritis
Cardiovascular Disease
Cholesterol (high)
Inflammation
Rheumatoid Arthritis
Triglycerides (high)

Products containing Stearidonic acid

We currently have no products on Vitabase that contain this ingredient.