Evidence supporting the use of: Ursane-type triterpenoid
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ursane-type triterpenoids, a class of natural compounds found in many medicinal plants (notably Centella asiatica and Eriobotrya japonica), have been investigated for their potential benefits in inflammatory conditions such as rheumatoid arthritis (RA). Scientific studies, particularly in vitro and animal models, suggest these triterpenoids—such as ursolic acid and asiatic acid—possess anti-inflammatory, immunomodulatory, and antioxidant properties. Mechanistically, they appear to suppress the production of pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6) and inhibit pathways central to RA pathology, such as NF-κB signaling. For instance, research published in Phytomedicine and International Immunopharmacology has demonstrated that ursolic acid reduces paw swelling and joint destruction in collagen-induced arthritis models in rodents, and decreases inflammatory mediators in cell-based assays.

However, the evidence remains primarily preclinical; there are currently no robust, large-scale human clinical trials specifically evaluating ursane-type triterpenoids for RA. The available data are promising but preliminary, justifying a modest evidence score. While some traditional systems of medicine use plants containing these compounds for joint pain, the linkage to RA specifically is not well-documented historically. Therefore, the current scientific support is limited and not yet sufficient for clinical recommendation.

More about Ursane-type triterpenoid
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Other ingredients used for Rheumatoid Arthritis

adrenal cortex
alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-pinene
anthocyanins
ashwagandha
astaxanthin
borage oil
celery
coenzyme Q10 (CoQ10)
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
dong quai root
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
evening primrose oil
fisetin
fish protein
gamma linolenic acid (GLA)
gamma tocopherol
genistein
ginger
green lipped mussel
krill oil
luteolin
methylsulfonylmethane (MSM)
myristoleate
omega-3 fatty acids
phospholipids
resveratrol
rose hips
sardines
slippery elm bark
sulforaphane glucosinolate
Urolithin A
vitamin B6
vitamin C
vitamin D
vitamin D3
watercress
white willow
alpinia galangal
smilax
fumaria parviflora
lingusticum wallichii
amber
teasel
guelder rose
gentiana macrophylla
abies spectabilis
AMP-activated protein kinase (AMPK)
clematis
15,16-Dihydrotanshinone I
Aralia
akebia
Antler
Apigenin
Abrus
Andrographolide
Amentoflavone
Alpha-Lipoic Acid
anthocyanidins
Ampelopsin
Actaea spicata
Acetylsalicylic acid
Arjunic Acid
Apocynin
Arctiin
Astragalin
Boswellic Acid
Baicalein
Bogbean
Boswellia
Black willow
Barbasco
bovine cartilage / glycosaminoglycan
Baicalin
Black Hellebore
Bee venom
Bergenia
Cod Liver Oil
Cortisol
Clerodendrum phlomidis
Cyanidin
Chinese Fleeceflower
Chinese Pond Turtle
Chuchuhuasi
Cetylated Fatty Acids
C-Phycocyanin
Cannabidiol
Carnosic acid
Docosahexaenoic Acid
Dihomo-gamma-linolenic acid
Eicosatetraenoic acid
Eicosapentaenoic Acid
Evening Primrose Oil
Fructoborate
Flemingia philippinensis
Frankincense
Flavanols
Flavones

Products containing Ursane-type triterpenoid

We currently have no products on Vitabase that contain this ingredient.