Evidence supporting the use of: Vitamin D (mixed)
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has been investigated for its potential role in supporting patients with rheumatoid arthritis (RA), primarily due to its immunomodulatory properties. Vitamin D receptors are expressed on various immune cells, and vitamin D can modulate immune response, which is relevant in autoimmune diseases like RA. Observational studies have found that people with RA often have lower serum vitamin D levels compared to healthy controls, and vitamin D deficiency has been associated with increased disease activity in some cohorts.

However, randomized controlled trials (RCTs) and meta-analyses have provided mixed results. Some small studies suggest that vitamin D supplementation may modestly reduce disease activity or improve symptoms in vitamin D-deficient RA patients, but the benefits are generally limited and inconsistent. Larger and more rigorous RCTs have not demonstrated a clear, clinically significant improvement in RA outcomes with vitamin D supplementation. Currently, major rheumatology guidelines do not recommend vitamin D specifically for RA treatment beyond correcting deficiency for bone health.

In summary, while there is a scientific rationale and some observational and interventional data suggesting a possible supportive role for vitamin D in RA, evidence of clear therapeutic benefit is limited. Supplementation may be considered for individuals who are deficient, but it should not be regarded as a primary or disease-modifying treatment for RA.

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