Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Malabar nut (Justicia adhatoda), also known as Vasaka, has a long history of use in traditional Ayurvedic and Unani medicine for a variety of respiratory conditions, including cough, asthma, and bronchitis. Its primary active constituents, vasicine and vasicinone, have demonstrated bronchodilatory, expectorant, and anti-inflammatory effects in preclinical studies. These properties provide a mechanistic rationale for its use in respiratory tract conditions that may involve inflammation and mucus overproduction, such as allergic rhinitis.

Recent scientific studies have begun to explore the potential of Malabar nut in allergic conditions. Some animal studies suggest that extracts of Justicia adhatoda can inhibit the release of histamine and other inflammatory mediators, which are drivers of allergic rhinitis symptoms. In one study published in a peer-reviewed journal, Malabar nut extract reduced nasal symptoms and demonstrated anti-allergic effects in animal models. However, direct clinical trials in humans specifically for allergic rhinitis are limited or lacking. Most human data are related to cough and asthma rather than allergic rhinitis per se.

In summary, while preclinical evidence supports the plausibility of Malabar nut alleviating symptoms of allergic rhinitis through its anti-inflammatory and anti-allergic actions, high-quality clinical studies in humans for this specific indication are sparse. Thus, the scientific evidence is emerging but not yet robust, justifying a moderate evidence rating.

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