Evidence supporting the use of: Perilla
For the health condition: Rhinitis, Allergic

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Perilla (Perilla frutescens), commonly used in traditional East Asian medicine, has garnered some scientific interest for its potential to support or treat allergic rhinitis. Several laboratory and clinical studies have investigated perilla leaf extract for its anti-allergic and anti-inflammatory properties. Perilla contains compounds such as rosmarinic acid and luteolin, which have demonstrated the ability to inhibit histamine release and modulate immune responses in vitro and in animal models.

A handful of small human clinical trials have explored the efficacy of perilla extracts in individuals with allergic rhinitis. For example, a 2004 double-blind, placebo-controlled study published in the journal Experimental Biology and Medicine found that perilla seed extract supplementation reduced nasal congestion and other allergy symptoms in a group of patients with seasonal allergic rhinitis. Additionally, a few other pilot studies have reported improvement in allergy symptoms after perilla supplementation.

However, the overall quality and size of clinical evidence are still limited. Most studies have small sample sizes, vary in extract preparations, and short durations. No large-scale, high-quality randomized controlled trials have been published to firmly establish perilla's efficacy for allergic rhinitis. Thus, while there is preliminary scientific support for perilla's use in allergic rhinitis, more robust human studies are needed to confirm its benefits and safety profile.

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