Evidence supporting the use of: Glycyrrhetinic acid
For the health condition: Rhinitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glycyrrhetinic acid—a bioactive compound derived from licorice root (Glycyrrhiza glabra)—has been investigated for its potential benefits in managing rhinitis, particularly allergic rhinitis. Several studies have explored its anti-inflammatory and anti-allergic properties. Glycyrrhetinic acid inhibits enzymes involved in the breakdown of endogenous corticosteroids, thus enhancing local anti-inflammatory effects. It has also been shown to inhibit the expression of pro-inflammatory cytokines and reduce eosinophil infiltration in nasal mucosa.

Clinical support includes randomized controlled trials where intranasal preparations containing glycyrrhetinic acid have demonstrated improvements in nasal symptoms, reduction in nasal eosinophilia, and decreased need for other medications in patients with allergic rhinitis. For example, a 2016 double-blind study (Passali et al., 2016) reported that nasal sprays containing glycyrrhetinic acid significantly improved symptoms in adults with allergic rhinitis compared to placebo. Other studies have investigated its use as an adjunct therapy, finding benefits when combined with standard treatments.

However, the overall evidence base remains moderate (hence a rating of 3). While there are positive findings, the number of high-quality, large-scale studies is still limited, and most existing research involves short-term use. In summary, glycyrrhetinic acid has some scientific support as a topical treatment for rhinitis—primarily due to its anti-inflammatory mechanisms—but further research is needed to confirm long-term efficacy and safety.

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