Evidence supporting the use of: Azelaic acid
For the health condition: Rosacea

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Azelaic acid is a well-established, scientifically validated treatment for rosacea. Multiple randomized, double-blind, placebo-controlled clinical trials have demonstrated that topical azelaic acid (typically in 15% gel or foam formulations) significantly reduces the inflammatory lesions and erythema associated with papulopustular rosacea. Its efficacy is comparable to, or in some cases superior to, other topical therapies such as metronidazole. Azelaic acid works through several mechanisms: it has anti-inflammatory properties, reduces reactive oxygen species, and inhibits the proliferation of Cutibacterium acnes and Staphylococcus epidermidis, which are implicated in the pathogenesis of rosacea. Additionally, it normalizes keratinization and reduces the production of pro-inflammatory cytokines. The safety profile of azelaic acid is favorable, with most adverse effects limited to mild, transient local irritation such as burning or stinging. Major dermatological societies, including the American Academy of Dermatology and the European Dermatology Forum, recommend azelaic acid as a first-line topical treatment for mild to moderate rosacea. Therefore, its use is strongly supported by high-quality scientific evidence and is considered a standard of care in modern dermatology.

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Products containing azelaic acid

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