Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bisabolol is a naturally occurring compound most commonly isolated from chamomile (Matricaria recutita) and is widely used in dermatological formulations for its soothing and anti-inflammatory properties. Its use in rosacea management is primarily supported by its demonstrated ability to inhibit pro-inflammatory cytokines, reduce skin irritation, and promote skin barrier repair in both in vitro and in vivo studies. Several studies indicate that bisabolol can suppress NF-κB pathway activation and decrease levels of TNF-α and IL-1β, which are thought to play roles in the inflammatory processes underlying rosacea. Furthermore, bisabolol exhibits antioxidant activity, which may also help counteract the oxidative stress associated with rosacea flare-ups.

However, there are limited high-quality, direct clinical trials specifically evaluating bisabolol as a monotherapy or adjunctive therapy for rosacea in humans. Most of the evidence consists of laboratory research, animal models, or broader studies on sensitive and inflamed skin. Its inclusion in rosacea-targeted formulations is largely based on these general anti-inflammatory and skin-calming effects, as well as its long-standing safety profile. Thus, while the scientific rationale exists and is supported by mechanistic data, there is a lack of robust clinical trial evidence directly confirming its efficacy in rosacea patients, warranting a moderate evidence rating.

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