Evidence supporting the use of: Allantoin
For the health condition: Scars / Scar Tissue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Allantoin is widely used in topical formulations for skin healing, including products marketed for scars and scar tissue. The scientific basis for its use primarily centers on its keratolytic, moisturizing, and skin-soothing properties. Allantoin can promote cell proliferation and accelerate epidermal healing in minor wounds and irritations, which are mechanisms theoretically helpful for scar management.

However, the direct evidence supporting allantoin’s effectiveness in reducing the appearance or formation of scars is limited. Most studies have focused on its general wound healing and skin barrier repair properties, with few clinical trials specifically targeting established scars or scar tissue. Some small studies and in vitro research suggest allantoin may help modulate fibroblast activity and extracellular matrix production, which are involved in scar formation. Its inclusion in combination products (such as onion extract-based gels) further complicates attribution of efficacy solely to allantoin.

Overall, while its safety and skin compatibility are well recognized, the evidence for allantoin’s direct impact on scars is weak to moderate, meriting a rating of 2 out of 5. Its use in this context is supported by plausible mechanisms and some supportive data, but definitive, high-quality clinical trials are lacking. Most endorsements stem from its long history of use in dermatology and its established benefits for general skin healing, rather than strong, scar-specific scientific validation.

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Products containing Allantoin

We currently have no products on Vitabase that contain this ingredient.