Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bisabolol, a natural monocyclic sesquiterpene alcohol derived primarily from chamomile (Matricaria recutita), is increasingly included in topical formulations aimed at improving the appearance and healing of scars and scar tissue. The rationale for its use is grounded in its well-documented anti-inflammatory, soothing, and skin-healing properties. Laboratory studies have demonstrated bisabolol's ability to modulate inflammatory responses by inhibiting pro-inflammatory cytokines and enzymes such as COX-2, which can be beneficial during the wound healing process that leads to scar formation. In addition, bisabolol has shown antioxidant activity, which may help protect skin cells from oxidative stress, a factor that can exacerbate scar formation.

However, while the theoretical basis and in vitro data are promising, direct clinical evidence for bisabolol’s efficacy in treating or reducing established scars in humans is limited. Most of the support comes from its inclusion in multi-ingredient scar gels or creams, where it is often combined with silicone, onion extract, or other botanicals. Controlled clinical trials isolating bisabolol as the sole active ingredient for scar treatment are rare. Therefore, while scientific mechanisms support its potential, the direct clinical evidence is modest, justifying a moderate evidence rating. Its use is scientifically motivated but not yet robustly validated by high-quality, large-scale human studies specifically targeting scars or scar tissue.

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