Evidence supporting the use of: Centella triterpenes
For the health condition: Scars / Scar Tissue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Centella triterpenes—primarily asiaticoside, madecassoside, asiatic acid, and madecassic acid—are bioactive compounds extracted from Centella asiatica (Gotu Kola). Their use in supporting the healing of scars and scar tissue is backed by both traditional usage and a growing body of scientific evidence. Several in vitro and in vivo studies suggest Centella triterpenes can modulate the wound healing process by promoting fibroblast proliferation, enhancing collagen synthesis (particularly type I and III collagen), and increasing the tensile strength of newly formed skin. Clinical trials and observational studies have found that topical preparations containing Centella triterpenes may reduce the formation of hypertrophic scars and keloids, improve scar appearance, and accelerate wound closure.

A 2013 review published in Advances in Dermatology and Allergology and other peer-reviewed sources highlight mechanisms such as inhibition of inflammatory mediators, stimulation of glycosaminoglycan synthesis, and antioxidant effects. Some randomized controlled trials have shown that patients using Centella-based creams after surgical procedures or burns experienced improved scar outcomes compared to controls. However, limitations include small sample sizes and heterogeneity in product formulations.

Overall, while there is traditional support for its use, there is also moderate-to-strong scientific evidence, particularly for topical application, in improving scar healing and appearance. More large-scale, high-quality clinical trials are warranted to strengthen and standardize these findings.

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Products containing Centella triterpenes

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