Evidence supporting the use of: Glycosaminoglycan
For the health condition: Scars / Scar Tissue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycosaminoglycans (GAGs), such as hyaluronic acid and chondroitin sulfate, are polysaccharides naturally found in the extracellular matrix of the skin and play a key role in tissue hydration, elasticity, and repair. Their use in supporting or treating scars and scar tissue has some scientific basis, particularly with hyaluronic acid, which is widely studied in dermatology and wound healing. Clinical and preclinical studies suggest that topical or injectable hyaluronic acid can modulate inflammation, promote fibroblast migration, and enhance the quality of wound healing, sometimes resulting in less visible or softer scars.

For example, a number of randomized controlled trials and reviews have indicated that hyaluronic acid-based dressings or gels can improve wound healing and may reduce hypertrophic scarring in certain contexts. However, evidence for other GAGs, such as chondroitin sulfate or dermatan sulfate, is less robust and primarily limited to experimental or animal studies. There is also limited direct evidence supporting the use of GAGs specifically for established (mature) scar tissue, as most studies focus on their role during the initial wound healing phase.

Overall, while there is some scientific support—especially for hyaluronic acid—the evidence base is not strong or comprehensive for all glycosaminoglycans or for all types of scars. Thus, the rating reflects modest but not definitive scientific validation.

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Products containing Glycosaminoglycan

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