Evidence supporting the use of: Hyaluronic acid
For the health condition: Scars / Scar Tissue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found in connective tissues, skin, and the extracellular matrix. Its use in the support and treatment of scars and scar tissue is primarily justified by scientific evidence, although the quality and quantity of evidence is moderate rather than robust. HA is well-known for its hydrating properties, but it also plays a role in tissue repair and wound healing. In preclinical and some clinical studies, HA-based topical formulations have been shown to enhance wound healing by promoting cell migration, angiogenesis, and modulating inflammation, which can potentially result in improved scar outcomes. Randomized controlled trials and systematic reviews (e.g., Campo et al., 2019) suggest HA may reduce erythema, pruritus, and the thickness of hypertrophic scars, particularly when combined with other ingredients (such as silicone or onion extract). However, most studies are small, heterogeneous, and sometimes industry-sponsored, which limits the strength of the conclusions. There is evidence supporting HA’s efficacy in post-surgical and burn scars, but less so for older or more established scars. Overall, HA is considered safe and potentially beneficial as part of a scar management regimen, but it should not be regarded as a stand-alone or primary treatment based on current evidence.

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