Evidence supporting the use of: Hyaluronidase
For the health condition: Scars / Scar Tissue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hyaluronidase has some scientific basis for use in the management of scars and scar tissue, though the evidence is limited and not robust. Hyaluronidase is an enzyme that breaks down hyaluronic acid, a major component of the extracellular matrix and connective tissue. Its primary medical use is to enhance the absorption and dispersion of injected drugs or fluids, and to treat complications such as hyaluronic acid filler overcorrection. In the context of scars and scar tissue, several small studies and case reports have explored the injection of hyaluronidase to soften or remodel hypertrophic scars, keloids, and fibrotic tissue, particularly when these are associated with previous cosmetic procedures or dermal filler complications. Some clinicians have reported that intralesional hyaluronidase can decrease scar firmness and volume, likely by breaking down excess extracellular matrix components. However, these reports are largely anecdotal or from uncontrolled studies. A few small case series, such as those addressing post-surgical or traumatic scarring, suggest modest improvements in scar pliability and appearance, but there is significant variability in outcomes. There are no large, well-controlled clinical trials establishing hyaluronidase as a routine treatment for scars or scar tissue. Current scientific support is thus limited to low-quality evidence and expert opinion. Most guidelines do not include hyaluronidase as a standard therapy for scars, and more research is needed to clarify its efficacy and safety for this indication.

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Products containing Hyaluronidase

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