Evidence supporting the use of: Tripeptide
For the health condition: Scars / Scar Tissue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tripeptides, particularly those like GHK (glycyl-L-histidyl-L-lysine) and palmitoyl tripeptide-1, have been studied for their role in wound healing and scar modulation. Scientific evidence suggests that certain tripeptides can stimulate collagen production, enhance extracellular matrix remodeling, and support skin regeneration, which are important factors in scar reduction. For example, GHK has been shown in some laboratory and animal studies to promote wound healing and reduce scar formation by modulating inflammation and stimulating the synthesis of collagen and glycosaminoglycans. Additionally, palmitoyl tripeptide-1 and similar peptides are used in cosmetic formulations aimed at improving scar appearance, with small clinical studies and in vitro research supporting their ability to boost collagen and elastin production.

However, the overall quality and quantity of clinical evidence specifically assessing tripeptides for the treatment of established scars in humans is limited. Most of the available evidence comes from preclinical studies, open-label trials, or research focused on wound healing rather than established scar tissue. Larger, well-controlled human trials are needed to conclusively determine their effectiveness for scar treatment. Thus, while there is promising scientific rationale and some early evidence, the support for tripeptide use in treating scars or scar tissue is moderate and not definitive.

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Products containing Tripeptide

We currently have no products on Vitabase that contain this ingredient.